Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
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B.Pharm. - SEMESTER-IV EXAMINATION - SUMMER - 2018Subject Code: 240005 Date: 21/05/2018
Subject Name: Pharmacology-I
Time: 10:30 AM TO 01:30 PM Total Marks: 80
Instructions:
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- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q.1 (a) Classify various routes of drug administration and write advantages and disadvantages of parenteral route. 06
(b) Describe steps involving in neurohumoral transmission. 05
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(c) Define following term: 05
- Pharmacodynamic
- Pharmacogenomics
- Pharmacokinetics
- Drug tolerance
- Teratogenicity
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Q.2 (a) Discuss absorption process and factors affecting to drug absorption. 06
(b) What is Dale’s vasomotor reversal of adrenaline and classify sympathomimetic agents. 05
(c) Explain competitive and non-competitive antagonism with suitable example. 05
Q.3 (a) Write a short note on: 06
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- Method prolonging the duration of action of drug
- Plasma protein binding.
(b) Enlist various types of receptor and describe GPCR in detail. 05
(c) Classify cholinergic drugs and write down pharmacological action of acetylcholine. 05
Q.4 (a) Write a short note on: 06
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- Structure activity relationship(SAR)
- First pass metabolism
- Bioavailability
(b) Enlist various types of drug interactions. Write in detail about pharmacokinetic drug interaction. 05
(c) Define autocoids. Write short note on H1 receptor blocker. 05
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Q.5 (a) Write down pharmacological action of histamine. 06
(b) Write a note on prostaglandins. 05
(c) Write phases of clinical trial. 05
Q.6 (a) Explain organophosphorous poisoning and its treatment. 06
(b) Write a note on pentagastrin and angiotensin. 05
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(c) Write a note on local anaesthetics. 05
Q.7 (a) Write a note on drug nomenclature and Define drug and explain different sources 06
(b) Write a note on neuro muscular blocking agents. 05
(c) Define following terms with example 05
- Potentiation
- Addition
- Synergism
- Agonist
- Partial antagonist
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