Seat No.:
Subject Code: 2250004
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Subject Name: Pharmaceutical Chemistry - VII (Medicinal Chemistry - I)
Time: 02:30 PM TO 05:30 PM
Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharm. - SEMESTER-5 * EXAMINATION - SUMMER -2018
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Instructions:
- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q.1
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(a) Classify the antiasthmatic agents with chemical structures. 06
(b) What is autocoids? Write the chemistry, biosynthesis and metabolism of histamine. 05
(c) Define neuromuscular blockers. Classify them with only names. Write the therapeutic uses of them. 05
Q.2
(a) Describe optical and geometric isomerism of drugs. How do they affect the drug’s biological activity? 06
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(b) Write the synthesis of 1) any one H1-antihistamine containing phenothiazine nucleus and 11) any one H1-antihistamine containing piperazine ring. 05
(c) Write a short note on indirectly acting sympathomimetics. 05
Q.3
(a) Define expectorants and mucolytics. Give two examples of expectorants and two examples of mucolytics with chemical structures. 06
(b) Classify the muscarinic agonists with chemical structures. 05
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(c) Write the synthesis of i) any one H+/K+-ATPase inhibitor and ii) any one ß-blocker. 05
Q.4
(a) Define medicinal chemistry. Discuss the history of it. 06
(b) Write the synthesis of neostigmine and salbutamol. 05
(c) Discuss the development of H2-antihistamines. Write the therapeutic uses of H2-antihistamines. 05
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Q.5
(a) Write the neurochemistry of acetylcholine. 06
(b) Classify the antiemetics with chemical structures. 05
(c) Explain the SAR of parasympatholytics. 05
Q.6
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(a) Differentiate antacids and antisecretory agents. Write the mechanism of action and examples with structures of proton pump inhibitors. 06
(b) Write a note on prokinetics. 05
(c) What is the measure of drug’s lipophilicity? How does it affect the drug’s biological activity? 05
Q.7
(a) What is eicosanoids? Describe the biosynthesis of prostaglandins. 06
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(b) Discuss various metabolic routes for norepinephrine. 05
(c) Write a short note on analeptics. 05
Total Marks: 80
Date: 21/05/2018
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