Download GTU B.Pharma 2018 Summer 5th Sem 250004 Pharmaceutical Chemistry Vi (Medicinal) Question Paper

Download GTU (Gujarat Technological University) B.Pharma (Bachelor of Pharmacy) 2018 Summer 5th Sem 250004 Pharmaceutical Chemistry Vi (Medicinal) Previous Question Paper

Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharm. - SEMESTER?5 ? EXAMINATION ? SUMMER -2018

Subject Code: 250004 Date: 21/05/2018
Subject Name: Pharmaceutical Chemistry - VI (Medicinal)
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

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Q.1 (a) How the following physicochemical properties of drug molecules influence the
biological activity. (i) Protein binding (ii) Partition coefficient
06
(b) Define i) Bioisosterism ii) Geometrical Isomerism iii) Optical isomerism 05
(c) Write notes on (i) Hydrogen bonding (ii) Redox potential 05

Q.2 (a) Complete the following reactions
(i) Furan + ammonia Al2O3

(ii) Pyrrole + chloroform Base

(iii) Isoquinoline [O]
Permanganate
06
(b) Write the synthesis with mechanism of the following
(i) Skraup Quinoline synthesis (ii) Fischer-Indole synthesis
05
(c) Give the reactions of thiazole and pyrimidine 05

Q.3 (a) Define antiasthmatics. Classify and give structure from each classification. 06
(b) Write a note on (i) Antitussive agent (ii) Decongestants 05
(c) Discuss SAR of (i) Ranitidine (ii) Omeprazole 05

Q.4 (a) Write the uses of the following drugs: (i) Noscapine (ii) Triamcinolone
(iii) Dimenhydrinate (iv) Methyl cellulose (v)Diphenoxylate (vi) Papaverine
06
(b) (b)Write notes on (i)Carminatives (ii) Prokinetics 05
(c) (c)Give the synthesis of (i)Ranitidine (ii) Omeprazole 05

Q.5 (a) Give the synthesis of the following drugs (i) Diphenhydramine
(ii) Tripelennamine (iii) Antazoline
06
(b) Write notes on i) Antiemetics ii) Laxatives 05
(c) Discuss the SAR of antihistamines 05

Q. 6 (a) What are Eicossanoids ? Classify with example. Discuss the biosynthesis and
pharmacological activities of prostaglandins
06
(b) Give the synthesis and IUPAC name of (i) Cetrizine (ii) Trimeprazine 05
(c) Write a note on (i) Local colorectal preparations (ii) Enzymes

05
Q. 7 (a) Define and classify diagnostic agents. Write a note on sodiumlothalamate and
diatrizoic acid
06
(b) Discuss the following (i)Mannich reaction of indole (ii) Sulphonation of pyridine 05
(c) Write the reactions of the following (i) Quinoline (ii) Imidazole 05
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