GTU B.Pharma 2018 Summer Question Papers || Gujarat Technological University
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Seat No.: Enrolment No.
B.Ph. - SEMESTER-6 EXAMINATION - SUMMER -2018
Subject Code:2260004 Date:08/05/2018
Subject Name: Pharmaceutical Chemistry VIII (Medicinal Chemistry IT)
Time: 10:30AM TO 01:30PM Total Marks: 80
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Write down Phase I metabolism in detail. 06
(c) What are the factors affecting drug metabolism. 05
Q.2 (a) Explain the theory of receptors in detail. 06
(b) Write a note on Phase II metabolism. 05
(c) Explain factors affecting the drug-receptor interactions 05
(b) Write down SAR of Tricyclic Antidepressant agents. 05
(c) Give IUPAC name and synthesis of Fluoxetine and Imipramine. 05
Q.4 (a) Classify barbiturates with examples. Give SAR of barbiturates. 06
(b) What are DMARDS? Give synthesis of Paracetamol. 05
Q.5 (a) What are antiepileptic drugs? Give them mechanism of action. Classify with examples. 05
(b) Write SAR-of butyrophenones. 05
(c) Give IUPAC name and synthesis of Phenytoin and Carbamazepine. 06
Q.6 (a) Write a note on Antiparkinson’s agents with examples. 05
(c) Write a short note Alzheimers disease. 05
Q.7 (a) What are NSAIDS? Classify them with examples giving one structure from each class. 05
(b) Write a note on Anti-Gout agents. 05
(c) Give IUPAC name and synthesis of Diclofenac and Ibuprofen. 05
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Seat No.: Enrolment No.
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GUJARAT TECHNOLOGICAL UNIVERSITYB.Ph. - SEMESTER-6 EXAMINATION - SUMMER -2018
Subject Code:2260004 Date:08/05/2018
Subject Name: Pharmaceutical Chemistry VIII (Medicinal Chemistry IT)
Time: 10:30AM TO 01:30PM Total Marks: 80
--- Content provided by FirstRanker.com ---
Instructions:1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Write down Phase I metabolism in detail. 06
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(b) Write a note on CYP450. 05(c) What are the factors affecting drug metabolism. 05
Q.2 (a) Explain the theory of receptors in detail. 06
(b) Write a note on Phase II metabolism. 05
(c) Explain factors affecting the drug-receptor interactions 05
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Q.3 (a) Give chemical classification of Antipsychotics and discuss the SAR of Phenothiazine. 06(b) Write down SAR of Tricyclic Antidepressant agents. 05
(c) Give IUPAC name and synthesis of Fluoxetine and Imipramine. 05
Q.4 (a) Classify barbiturates with examples. Give SAR of barbiturates. 06
(b) What are DMARDS? Give synthesis of Paracetamol. 05
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(c) Give IUPAC name and synthesis of Halothane and Lignocaine. 05Q.5 (a) What are antiepileptic drugs? Give them mechanism of action. Classify with examples. 05
(b) Write SAR-of butyrophenones. 05
(c) Give IUPAC name and synthesis of Phenytoin and Carbamazepine. 06
Q.6 (a) Write a note on Antiparkinson’s agents with examples. 05
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(b) Write a short note on cognition enhancer. 05(c) Write a short note Alzheimers disease. 05
Q.7 (a) What are NSAIDS? Classify them with examples giving one structure from each class. 05
(b) Write a note on Anti-Gout agents. 05
(c) Give IUPAC name and synthesis of Diclofenac and Ibuprofen. 05
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