Download GTU B.Pharma 2018 Summer 8th Sem 2280001 Dosage Form Design Ii Question Paper

Download GTU (Gujarat Technological University) B.Pharma (Bachelor of Pharmacy) 2018 Summer 8th Sem 2280001 Dosage Form Design Ii Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharm. - SEMESTER?8 ? EXAMINATION ? SUMMER -2018
Subject Code: 2280001 Date: 28/04/2018
Subject Name: Dosage form Design II
Time: 10:30 AM TO 01:30 PM
Total Marks: 80

Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Enlist various methods of preparation of microspheres and explain double 06
emulsion method in detail.

(b) Explain influence of extraction ratio in hepatic clearance.
05

(c) Enlist different types of hydrogels and explain in situ gel in detail.
05



Q.2 (a) Enumerate various parenteral drug delivery system and explain any one in 06
detail.

(b) Write short note on Michaeles Menton Equation.
05

(c) Explain importance of tortuosity and porosity in dissolution.
05



Q.3 (a) Write a note on pharmacokinetic drug interactions with examples.
06

(b) Discuss ideal characteristics of drug eligible for transdermal drug delivery 05
system.

(c) Explain lag time and burst effect in controlled drug delivery system with 05
diagram.



Q.4 (a) Explain catenary and mammillary compartment models in detail.
06

(b) Briefly explain colon targeted osmotic drug delivery system.
05

(c) Discuss in brief, effect of disease on colonic absorption of drugs.
05



Q.5 (a) Explain in detail, evaluation parameters of transdermal patch.
06

(b) Differentiate liposomes and niosomes.
05

(c) Write a note on reservoir type of controlled drug delivery system.
05



Q. 6 (a) Enlist different types of targeted drug delivery system and explain any one in
06
detail.

(b) Give example of hydrophobic type of matrix system and explain mechanism of
05
drug release from it.

(c) Explain appropriately with equations if necessary, dosage adjustment in 05
patients with renal failure.



Q.7 (a) Write short note on Pulsincap with appropriate figure.
06

(b) Elaborate effervescent system in GRDDS.
05

(c) Define Cmax, Volume of distribution, compartment model, Total clearance and 05
Clinical pharmacokinetics.
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