Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
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Pharm D — 1st Year EXAMINATION - SUMMER - 2018
Subject Code:818803 Date: 23/05/2018
Subject Name: Medicinal Biochemistry
Time:10:30AM TO 01:30PM Total Marks: 70
Instructions:
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- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q.1
(a) Discuss at length the process of beta oxidation of fatty acids with energetics 06
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(b) Discuss about defective metabolism of lipids 04
(c) Explain ketone bodies formation and their utilization 04
Q.2
(a) Classify proteins according to their biological functions. Write about kwashiorkor and marasmus. 06
(b) Discuss urea cycle 04
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(c) Discuss about abnormal metabolism of proteins 04
Q.3
(a) Explain citric acid cycle with its energetic 06
(b) Define coenzymes. Explain their biochemical role and deficiency diseases 04
(c) Discuss specificity of enzymes 04
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Q.4
(a) Explain (1) cori’s cycle (2) Glycogen storage disorders 06
(b) Describe the components of electron transfer chain and discuss the oxidation of NADH 04
(c) Discuss about uncouplers as inhibitors of oxidative phosphorylation 04
Q.5
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(a) Describe the hexose monophosphate shunt and add a note on its significance 06
(b) Write a note on distribution of water and water balance in humans 04
(c) Write in brief about the different laboratory investigations employed to assess liver functions 04
Q.6
(a) Write note on energy rich compounds 06
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(b) Write briefly on the renal function tests 04
(c) Discuss about (1) role of clinical chemistry laboratory (2) composition and functions of lipoproteins 04
Q.7
(a) Write note on damage and repair of DNA 06
(b) Discuss about Gene expression in eukaryotes 04
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(c) Write note on RIA 04
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