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Seat No.: Enrolment No.
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GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharm. - SEMESTER-8 EXAMINATION - SUMMER -2018
Subject Code: 280001 Date: 28/4/2018
Subject Name: Dosage form Design 11
Time: 10:30 AM TO 01:30 PM Total Marks: 80
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Instructions:
- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q1 (a) Explain various biological factors to be considered in the design of 06 sustained release dosage forms.
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(b) Write a note on Bio erodible controlled drug delivery systems. 05
(c) Enlist various physicochemical factors to be considered in the design 05 of sustained release dosage forms. Discuss the effect of porosity and tortuosity on release rate of sustained release formulations.
Q.2 (a) Discuss evaluation of release characteristics for the final dosage form 06 with respect to oral controlled release formulations.
(b) Explain non erodible and erodible ocular control release system. 05
(c) Write a note on burst effect with respect to controlled release 05 diffusional systems.
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Q.3 (a) Explain in detail about approaches for colon targeted drug delivery 06 system.
(b) Write a note-on evaluation of Transdermal drug delivery system. 05
(c) Explain‘in brief preparation of microspheres. 05
Q.4 (a) Discuss the formulation of parenteral emulsions and suspensions. 06
(b) Explain various types of osmotic pressure controlled systems with 05 suitable diagram.
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(c) Write a note on various classes of matrix tablets with respect to 05 modified drug release dosage forms.
Q.5 (a) Draw typical plasma concentration time profile curve. Explain 06 Pharmacokinetic and Pharmacodynamics parameters in brief.
(b) Give advantages and disadvantages of compartment modeling. 05
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(c) A drug has an elimination half life of 8 h and follows first order 05 kinetics. If a single dose 200mg is given to an adult male patient (68 kg) by i.v. bolus injection, calculate the percent of the dose lost in 24h.
Q.6 (a) Define clinical pharmacokinetics. Explain methods for the 06 calculation of creatinine clearance from serum creatinine concentration.
(b) Define drug interaction. Discuss interactions that involve a change in 05 drug absorption from GIT with suitable examples.
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(c) Explain dosage adjustment in patients with renal and hepatic failure. 05
Q.7 (a) Explain how one can detect nonlinear pharmacokinetics? Explain 06 Michaelis Menten equation for capacity limited process.
(b) Describe One- compartment open model kinetic after iv bolus 05 administration.
(c) Write merits of non- compartmental analysis. Explain AUC & 05 AUMC plots
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This download link is referred from the post: RGUHS B.Pharm 3rd Year 2020 Previous Question Papers - Rajiv Gandhi University of Health Sciences
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