Download GTU B.Pharma 2017 Winter 8th Sem 280001 Dosage Form Design Ii Question Paper

Download GTU (Gujarat Technological University) B.Pharma (Bachelor of Pharmacy) 2017 Winter 8th Sem 280001 Dosage Form Design Ii Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Ph. SEMESTER? VIII? EXAMINATION ? WINTER-2017
Subject Code: 280001
Date: 02-11-2017
Subject Name: Dosage Form Design-II
Time: 02:30 pm to 05:30 pm
Total Marks: 80
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Give the difference between sustained and controlled drug delivery system.
06
Describe the evaluation of oral controlled drug delivery system.

(b) Describe the advantage, disadvantage and limitation of sustained release
05
formulation.

(c) Describe loading and maintenance dose in controlled release formulation with
05
equations.



Q.2 (a) Explain Pharmacokinetic. Explain typical plasma level time curve affect single
06
oral dose.

(b) Describe Wegner-Nelson method for determination of adsorption rate constant.
05

(c) Explain in detail compartmental and non compartmental approach.
05



Q.3 (a) Mention the method of evaluation of microspheres in detail.
06

(b) Classify the polymer used in preparation of matrix tablet. Give two name of
05
each class.

(c) What is Nano particle. Give any one method in detail for preparation of Nano
05
particle.



Q.4 (a) Explain renal clearence. Describe graphical method for determination of renal
06
clearance.

(b) Write a note on osmotic ocular inserts. Explain parts of ocular inserts.
05

(c) Explain non linear pharmacokinetic using michaeles menten equation.
05



Q.5 (a) Describe the ideal requirements for Sustained release formulation. Explain lag
06
time, burst effect and reservoir system with respect to controlled release
formulation.

(b) Explain Pharmacokinetic and Pharmacodynamic parameters to be consider for
05
designing modified drug delivery system.

(c) Write a note on Hydrogel.
05



Q. 6 (a) Discuss Mechanism of release of drug from controlled release drug delivery
06
system.

(b) Explain the Pharmaceutical approach to develop colonic drug delivery system
05
in brief.

(c) Explain Volume of distribution and distribution coefficient.
05



Q.7 (a) What criteria are necessary for selection of drug as a candidate for controlled
06
release formulation. Explain each in brief.

(b) Define clinical pharmacokinetic and explain dosage adjustment in patient with
05
renal failure.

(c) Discuss the formulation of parenteral emulsion and suspension.
05
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