Download Pharm D 1st Year 2011 Oct 383804 Pharmaceutical Organic Chemistry Question Paper

Download Pharm-D (Doctor of Pharmacy) 1st Year (First Year) 2011 Oct 383804 Pharmaceutical Organic Chemistry Previous Question Paper

[KZ 804] OCTOBER 2011 Sub. Code: 3804
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
FIRST YEAR
PAPER IV ? PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. Code: 383804
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
(Max.) (Max.) (Max.)
1. a) Define Electrophilic aromatic substitution reaction.
Explain the mechanism of nitration, sulphonation, 17 40 min. 20
halogenation and Friedel craft?s alkylation reactions
with examples.
b) Write a note on activating and deactivating O, P, and
M directing groups.
2. a) Compare aliphatic nucleophilic bimolecular and
unimolecular reaction. (SN
2
vs SN
1
). 17 40 min. 20
b) Explain the mechanism and kinetics of 1, 2
Elimination reactions. (E
2
and E
1
).
II. Write notes on :
1. Write a note on Markownikoff?s rule and Peroxide effect. 4 10 min. 6
2. Explain about electrophilic addition of conjugated dienes. 4 10 min. 6
(1, 2 versus 1, 4 addition).
3. Write about the mechanism of Cannizaro?s reaction withexample. 4 10 min. 6
4. Define polarity of molecules and intermolecular forces with
examples. 4 10 min. 6
5. Explain Bayer?s strain theory with its merits and limitations. 4 10 min. 6
6. Explain Kolbe?s reaction and Reimer -Tiemann?s reaction. 4 10 min. 6
7. Write a note on allyl radical as a resonance hybrid. 4 10 min. 6
8. Write a note on oxidation-reduction reactions with examples. 4 10 min. 6
9. Give an example for free radical halogenation of alkenes with
respect to carbon ? carbon double bond acting as substituent. 4 10 min. 6
10. Define orientation, reactivity and stability. 4 10 min. 6

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