Download Pharm D 1st Year 2011 Oct 383804 Pharmaceutical Organic Chemistry Question Paper

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[KZ 804] OCTOBER 2011 Sub. Code: 3804

DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION

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FIRST YEAR

PAPER IV - PHARMACEUTICAL ORGANIC CHEMISTRY

O.P. Code: 383804

Time: Three Hours Maximum: 100 marks

Answer ALL questions in the same order.

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I. Elaborate on : Pages Time Marks

(Max.) (Max.) (Max.)

1. a) Define Electrophilic aromatic substitution reaction. Explain the mechanism of nitration, sulphonation, halogenation and Friedel craft’s alkylation reactions with examples. 17 40 min. 20

   b) Write a note on activating and deactivating O, P, and M directing groups.

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2. a) Compare aliphatic nucleophilic bimolecular and unimolecular reaction. (SN₁ vs SN₂). 17 40 min. 20

   b) Explain the mechanism and kinetics of 1, 2 Elimination reactions. (E₁ and E₂).

II. Write notes on :

1. Write a note on Markownikoff’s rule and Peroxide effect. 4 10min. 6

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2. Explain about electrophilic addition of conjugated dienes. 4 10min. 6

   (1, 2 versus 1, 4 addition).

3. Write about the mechanism of Cannizaro’s reaction with example. 4 10min. 6
4. Define polarity of molecules and intermolecular forces with examples. 4 10min. 6
5. Explain Bayer’s strain theory with its merits and limitations. 4 10min. 6

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6. Explain Kolbe’s reaction and Reimer -Tiemann’s reaction. 4 10min. 6
7. Write a note on allyl radical as a resonance hybrid. 4 10min. 6
8. Write a note on oxidation-reduction reactions with examples. 4 10min. 6
9. Give an example for free radical halogenation of alkenes with respect to carbon — carbon double bond acting as substituent. 4 10min. 6
10. Define orientation, reactivity and stability. 4 10min. 6

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