Sub. Code: 3804
PHARM. D DEGREE EXAMINATION
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(2009-2010 Regulation)
FIRST YEAR
PAPER IV - PHARMACEUTICAL ORGANIC CHEMISTRY
O.P. Code : 383804
Time : Three hours Maximum : 70 Marks
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I. Elaborate on: (4 x 10 =40)
- What do you understand by the term aromatic electrophilic substitution reaction and its general mechanism? Discuss the aromatic electrophilic substitution reactions, sulphonation and Friedel-Crafts alkylation reaction.
- What are Baeyer's strain theory and its limitations? Discuss the relative stability of cyclohexane.
- Discuss the reaction, mechanism and its synthetic application of
a) Sandmeyer's reaction b) Reformatsky reaction - Discuss electrophilic and free radical reactions in alkenes.
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II. Write notes on: (6x5=30)
- Polarity of bond and molecules.
- Stereoisomerism.
- With example, explain the mechanism of SN1 reaction.
- 1, 2 — addition versus 1,4 — addition reaction in conjugated dienes.
- Nucleophilic aromatic substitution reactions.
- Discuss the preparation, assay and uses of Dimercaprol.
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