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[LH 817] OCTOBER 2015 Sub. Code: 3817
PHARM. D DEGREE EXAMINATION
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(2009-2010 Regulation)
THIRD YEAR
PAPER V - MEDICINAL CHEMISTRY
Q.P. Code : 383817
Time: Three Hours Maximum: 70 marks
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Answer ALL questions
- Elaborate on : (4 x10=40)
- Classify alkylating agents. Discuss in detail the mechanism of action and SAR of alkylating agents.
- Enumerate various electronic and solubility parameters in QSAR.
- Describe briefly on various approaches of prodrug design.
- Briefly discuss the mechanism of action and SAR of azole antifungals.
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- Write notes on : (6x5=30)
- Write a short note on antihyperlipidemic agents.
- Write the structure, mechanism of action and synthesis of pyrazinamide.
- Write the structure and uses of any two diagnostic agents.
- Write the structure, mechanism of action and synthesis of amantadine.
- Write a short note on amino glycoside antibiotics.
- Write a note on molecular mechanics.
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