Pharm D Last 12 Years 2010-2022 Question Papers (1st Year, 2nd Year, 3rd Year, 4th Year and 5th Year)
[KZ 823] OCTOBER 2011 Sub. Code: 3823
DOCTOR OF PHARMACY (PHARM. D / POST BACCALAUREATE) DEGREE EXAMINATION
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FOURTH YEAR
PAPER V - BIOPHARMACEUTICS AND PHARMACOKINETICS
O.P. Code: 383823
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
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I. Elaborate on :
| Pages (Max.) | Time (Max.) | Marks (Max.) | |
|---|---|---|---|
| 1. a) Define Absorption. Explain the various mechanisms of drug absorption. | 17 | 40 min. | 20 |
| b) Explain the various models of pharmacokinetic analysis. | |||
| 2. a) Elaborate the various methods of improving bioavailability of poorly soluble drugs. | 17 | 40 min. | 20 |
| b) Explain Oxidation — reduction cycle. |
II. Write notes on :
| 1. Explain the BCS system? | 4 | 10min. | 6 |
| 2. What are the objectives and approaches in developing in vitro-in vivo correlation? | 4 | 10min. | 6 |
| 3. Pharmacodynamic methods for assessing bioavailability. | 4 | 10min. | 6 |
| 4. What are the physiological barriers of distribution? Add a note on BBB. | 4 | 10min. | 6 |
| 5. Describe briefly about plasma proteins | 4 | 10min. | 6 |
| 6. Explain Wagner Nelson method for computing absorption rate constant | 4 | 10min. | 6 |
| 7. Apparent volume of distribution and its significance | 4 | 10min. | 6 |
| 8. Define dose-dependent kinetics. Give some tests to detect the same in a rate process. | 4 | 10min. | 6 |
| 9. Explain the rate of excretion method for the determination of elimination rate constant. | 4 | 10min. | 6 |
| 10. A drug was administered by IV infusion at a rate of 20mcg/hr. the volume of distribution and elimination rate constant was found to be 10L and 0.2hr-1. Calculate steady state concentration achieved by the drug and the loading dose to be administered for achieving steady state concentration. | 4 | 10 min. | 6 |
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