Download Pharm D 4th Year 2011 Oct 383823 Biopharmaceutics And Pharmacokinetics Question Paper

Download Pharm-D (Doctor of Pharmacy) 4th Year (Fourth Year) 2011 Oct 383823 Biopharmaceutics And Pharmacokinetics Previous Question Paper

[KZ 823] OCTOBER 2011 Sub. Code: 3823
DOCTOR OF PHARMACY (PHARM. D / POST BACCALAUREATE)
DEGREE EXAMINATION
FOURTH YEAR
PAPER V ? BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. Code: 383823
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
(Max.) (Max.) (Max.)
1. a) Define Absorption. Explain the various mechanisms of
drug absorption. 17 40 min. 20
b) Explain the various models of pharmacokinetic analysis.
2. a) Elaborate the various methods of improving bioavailability
of poorly soluble drugs. 17 40 min. 20
b) Explain Oxidation ? reduction cycle.
II. Write notes on :
1. Explain the BCS system? 4 10 min. 6
2. What are the objectives and approaches in developing
in vitro-in vivo correlation? 4 10 min. 6
3. Pharmacodynamic methods for assessing bioavailability. 4 10 min. 6
4. What are the physiological barriers of distribution?
Add a note on BBB. 4 10 min. 6
5. Describe briefly about plasma proteins 4 10 min. 6
6. Explain Wagner Nelson method for computing absorption
rate constant 4 10 min. 6
7. Apparent volume of distribution and its significance 4 10 min. 6
8. Define dose-dependent kinetics.
Give some tests to detect the same in a rate process. 4 10 min. 6
9. Explain the rate of excretion method for the determination
of elimination rate constant. 4 10 min. 6
10. A drug was administered by IV infusion at a rate of 20mcg/hr. the
volume of distribution and elimination rate constant was found to
be 10L and 0.2hr
-1
. Calculate steady state concentration achieved 4 10 min. 6
by the drug and the loading dose to be administered for achieving
steady state concentration.
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