Download Pharm D 4th Year 2013 April 383823 Biopharmaceutics And Pharmacokinetics Question Paper

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[LC 823] APRIL 2013 Sub. Code: 3823

DOCTOR OF PHARMACY (PHARM. D / POST BACCALAUREATE) DEGREE EXAMINATION

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FOURTH YEAR

PAPER V —- BIOPHARMACEUTICS AND PHARMACOKINETICS

Q.P. Code: 383823

Time: Three Hours Maximum: 100 marks

Answer All questions

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1. Elaborate on: (2x20=40)
   1. Discuss the principles that governs the renal excretion of drugs?
   2. Discuss in detail the physiochemical factors affecting drug absorption?
2. Write notes on: (10 x 6 =60)
   1. Write a note on drug — drug interactions in Gastro intestinal tract?
   2. Discuss the importance of salivary excretion of drugs?

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   3. Derive the equation for one compartment open model intravenous infusion?
   4. Write the procedure involved in the determination of-elimination rate constant using urinary excretion data?
   5. Derive the equation for two compartment open- model extravascular administration?
   6. Write a note on Michaelis menten equation?
   7. Discuss in detail regulatory requirements for bioavailability study?

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   8. The dose of amoxicillin capsule was 500 mg and the AUC was 50.9 mcghr/L. The dose of suspension was'500 mg and the AUC is 6 1.93 mcghr/L. Calculate the relative bioavailability of capsule to the oral suspension.
   9. An ophthalmic solution of mydriatic drug at 5 mg/ml exhibits first order degradation with rate of 0.0005 /day. How much drug will remain after 120 days?
   10. Differentiate passive diffusion and active transport?

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