Download Pharm D 4th Year 2013 Oct 383823 Biopharmaceutics And Pharmacokinetics Question Paper

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[LD 823] OCTOBER 2013 Sub. Code: 3823

DOCTOR OF PHARMACY (PHARM. D / POST BACCALAUREATE) DEGREE EXAMINATION

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FOURTH YEAR

PAPER V - BIOPHARMACEUTICS AND PHARMACOKINETICS

Q.P. Code: 383823

Time: Three Hours Maximum: 70 marks

Answer All questions

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1. Elaborate on: (2x20=40)
   1. Define drug absorption. Discuss the various factors influencing GI absorption of a drug.
   2. Discuss the one compartment open model intravenous administration.
2. Write notes on: (10x 3 =30)
   1. Explain in brief about Michaelis Menten equation.
   2. Explain the Mean residence time.

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   3. Apparent volume of distribution.
   4. Methods to enhance the bioavailability through enhancement of drug solubility.
   5. How will you find out K_m and V_max from steady state concentration?
   6. What are the major parameters studied in the urinary excretion data?
   7. What are the factors affecting drug dissolution and dissolution rate?

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   8. Write the concept and types of clearance.
   9. The drug has an elimination half life of 6 hrs. and follows first order kinetics. If a single dose of 500 mg is given to an adult male (68 kg) patient by I.V bolus injection, what will be the percentage of dose lost in 24 hrs.?
   10. Statistical moment theory.

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