[LF 823] OCTOBER 2014 Sub. Code: 3823
DOCTOR OF PHARMACY (PHARM. D/ POST BACCALAUREATE) DEGREE EXAMINATION
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(2009-2010 Regulation)
FOURTH YEAR
PAPER V - BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. Code: 383823
Time: Three Hours Maximum: 70 marks
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Answer All questions
- Elaborate on: (4 x10=40)
- Define absorption. Explain briefly about different mechanisms of drug absorption.
- Advantages, Criteria of urinary excretion data. How will you find out elimination rate constant from the data?
- Bioequivalence study protocol.
- Multiple dosage regimens.
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- Write notes on: (6x5=30)
- Partition theory and its modifications.
- Blood Brain Barrier.
- Significance of protein binding.
- Catenary model.
- Wagner Nelson Method.
- Theophylline was administered to a patient at a dosing rate of 600 mg/day and 1200 mg/day. Respective steady state concentrations were 9.8 mg/L and 28.6mg/L. Find out K and Vd. Determine the dosing rate to achieve steady state concentration of 15 mg/L.
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