Download Pharm D 4th Year 2017 May 383823 Biopharmaceutics And Pharmacokinetics Question Paper

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[LK 823] MAY 2017 Sub. Code: 3823

PHARM. ‘D’ AND PHARM. ‘D’ (POST BACCALAUREATE) DEGREE EXAMINATION

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(2009-2010 Regulation)

FOURTH YEAR

PAPER V — BIOPHARMACEUTICS AND PHARMACOKINETICS

Q.P. Code : 383823

Time : Three hours Maximum : 70 Marks

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1. I. Elaborate on: (4 x 10 =40)

   1. Define drug absorption. Discuss the physiochemical factors influencing GI absorption of a drug.

   2. Explain briefly two compartmental open model extra Vascular Administration.

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   3. Explain in details about pharmacokinetic and pharmacodynamic parameters.

   4. What are the major parameters studied in the urinary excretion data?

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2. II. Write notes on: (6x5=30)

   1. Measurement of bioavailability.

   2. Explain the mean residence time.

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   3. Volume of distribution.

   4. Methods to enhance the bioavailability through enhancement of dissolution rate.

   5. How can you graphically estimate K_m and V_max from steady state concentration?

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   6. Hepatic clearance and renal clearance.

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