Download Pharm D 5th Year 2014 April 383827 Clinical Pharmacokinetics And Pharmacotherapeutic Drug Monitoring Question Paper

Download Pharm-D (Doctor of Pharmacy) 5th Year (Fifth Year) 2014 April 383827 Clinical Pharmacokinetics And Pharmacotherapeutic Drug Monitoring Previous Question Paper

[LE 827] APRIL 2014 Sub. Code: 3827
DOCTOR OF PHARMACY (PHARM. D / POST BACCALAUREATE)
DEGREE EXAMINATION
FIFTH YEAR
PAPER III ? CLINICAL PHARMACOKINETICS AND
PHARMACOTHERAPEUTIC DRUG MONITORING
Q.P. Code: 383827
Time: Three Hours Maximum: 70 marks
Answer All questions
I. Elaborate on: (2 x 20 = 40)
1. a) Explain the dose adjustment in renal disease with respect to total body clearance
and elimination rate constant?
b) Write a note on dosing of drugs in hepatic disease?
2. a) Explain dosing with feedback procedure in population pharmacokinetics?
b) Discuss in detail the methods adopted in the analysis of population pharmacokinetic
data?
II. Write notes on: (10 x 3 = 30)
1. Write a note on indications for therapeutic drug monitoring.
2. How will you calculate the drug dose for neonates, infants and children?
3. How will you determine renal dysfunction in patients?
4. Write a note on genetic polymorphism in drug metabolism?
5. Discuss about regional pharmacokinetics?
6. Explain the adverse reactions attributed to genetic differences
7. Differentiate Hemodialysis and Hemoperfusion?
8. How will you adjust the dose for uremic patients?
9. Discuss the importance of Bayesian theory?
10. Explain absorption based drug interactions with examples?

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