Download Pharm D 5th Year 2015 April 383827 Clinical Pharmacokinetics And Pharmacotherapeutic Drug Monitoring Question Paper

Download Pharm-D (Doctor of Pharmacy) 5th Year (Fifth Year) 2015 April 383827 Clinical Pharmacokinetics And Pharmacotherapeutic Drug Monitoring Previous Question Paper

[LG 827] APRIL 2015 Sub. Code: 3827
DOCTOR OF PHARMACY (PHARM. D / POST BACCALAUREATE)
DEGREE EXAMINATION
(2009-2010 Regulation)
FIFTH YEAR
PAPER III ? CLINICAL PHARMACOKINETICS AND
PHARMACOTHERAPEUTIC DRUG MONITORING
Q.P. Code: 383827
Time: Three Hours Maximum: 70 marks
Answer All questions
I. Elaborate on: (4 x 10 = 40)

1. Explain plasma concentration monitoring of drugs during clinical use.
2. Explain the various methods to calculate the creatinine clearance from serum
creatinine concentration.
3. The elimination half-life of an antibiotic is 3hrs with an apparent volume of
distribution equivalent to 20% of body weight. The usual therapeutic range
for this antibiotic is between 5 and 15?g/ml. Adverse toxicity for this drug is
often observed at serum concentration greater than 20?g/ml.
Calculate a dosage regimen (multiple IV doses) that will just maintain the serum
drug concentration between 5 and 15?g/ml.
4. Explain the polymorphism in Cytochrome isoenzymes.
II. Write notes on: (6 x 5 = 30)
1. Determination of rate of administration.
2. Explain Nonlinear mixed effect model.
3. How is dosing interval determined on the basis of therapeutic index of the drug?
4. Application of clinical pharmacokinetics.
5. Give dose adjustment based on the following:
a) Elimination rate constant.
b) Half life.
6. General approach for dose adjustment in renal disease.
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