PHARM. ‘D’ AND PHARM. ‘D’ (POST BACCALAUREATE) DEGREE EXAMINATION (2009-2010 Regulation) FIFTH YEAR
PAPER III - CLINICAL PHARMACOKINETICS & PHARMACOTHERAPEUTIC DRUG MONITORING
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Q.P. Code : 383827
Time: Three Hours Maximum: 70 marks
Answer ALL questions
- Elaborate on : (4 x10=40)
- Explain the determination of dose and dosing interval.
- Enumerate the pharmacokinetic drug interactions with examples.
- What is therapeutic drug monitoring? Add note on therapeutic drug monitoring of Psychiatric Drugs and Immunosuppressants.
- Explain the Pharmacogenetic & Nongenetic influences on Variations in Drug Therapy.
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- Write notes on : (6x5=30)
- Brief about the dosage regimen based on population-average.
- Write the note on extra corporeal removal of the drug.
- Discuss the adaptive method for dosing.
- Brief the Genetic polymorphism in Drug Transport with example.
- Describe the measurement of creatinine clearance.
- Note on adverse drug reaction attributed to genetic differences.
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