PTU (Punjab Technical University) B.Pharmacy Sixth Semester May 2019 Question Paper
Total No. of Pages : 02
Total No. of Questions : 10
B.Pharma (2011 to 2016) (Sem.?6)
PHARMACEUTICAL CHEMISTRY-VI
(Medicinal Chemistry-I)
Subject Code : BPHM-601
M.Code : 71033
Time : 3 Hrs. Max. Marks : 80
INSTRUCTION TO CANDIDATES :
1.
SECTION-A is COMPULSORY consisting of FIFTEEN questions carrying T WO
marks each.
2.
SECTION-B contains FIVE questions carrying FIVE marks each and students
have to attempt any FOUR questions.
3.
SECTION-C contains FOUR questions carrying T EN marks each and students
have to attempt any T HREE questions.
SECTION-A
1.
Answer briefly :
a) Non-classical bioisosterism
b) Lead optimization
c) Nicotinic action of Acetylcholine
d) Enzymes involved in the metabolism of Catecholamines
e) Oxicam
f) F-type prostaglandins
g) Parkinsonism
h) Thromboxane
i) Structure of histamine
j) H2-receptor
k) Role of nicotinamide
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l) Biotin
m) Calciferol
n) Conformational isomers of Acetylcholine
o) Serendipitous way of drug designing.
SECTION-B
2)
Comment on storage and release of Acetylcholine hydrochloride.
3)
What are antispasmodics? Give synthesis and mode of action of Dicyclomine
hydrochloride.
4)
Give synthesis, mode of action and uses of Gallamine triethiodide.
5)
Give synthesis, mode of action and uses of Pyrodigostigmine
6)
Name water soluble vitamins. Discuss chemistry of vitamin C.
SECTION-C
7)
Describe factors affecting drug receptor interactions.
8)
Discuss general SAR of H1 receptor antagonist.
9)
Describe conjunction and disjunction methods of drug designing by citing at least one
example of each.
10)
Discuss SAR of 3,5-Pyrazolidinedione derivatives for their anti-inflammatory activity.
Give synthesis, mode of action of phenylhydrazone.
NOTE : Disclosure of identity by writing mobile number or making passing request on any
page of Answer sheet will lead to UMC against the Student.
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( S 4 ) - 9 5
This post was last modified on 05 November 2019