Download PTU (Punjab Technical University) M-Pharma (Master of Pharmacy) 2nd Semester 74931 ADVANCED BIOPHARMACEUTICS AND PHARMACOKINETICS Last 10 Years 2020, 2019, 2018, 2017, 2016, 2015, 2014, 2013, 2012, 2011 and 2010 Previous Question Papers.
Roll No. Total No. of Pages : 01
Total No. of Questions : 06
M.Pharmacy(Industrial Pharmacy) (2017 Batch) (Sem.?2)
ADVANCED BIOPHARMACEUTICS AND PHARMACOKINETICS
Subject Code : MIP-201T
M.Code : 74931
Time : 3 Hrs. Max. Marks : 75
INSTRUCTIONS TO CANDIDATES :
1. Attempt any FIVE questions out of SIX questions.
2. Each question carries FIFTEEN marks.
Q.1 a. Name various theories explaining drug dissolution and enlist the factors affecting
dissolution rate. 8
b. Discuss the limitations and significance of pH-partition hypothesis. 7
Q.2 Discuss various methods used for bioavailability enhancement by enhancing permeability
of drugs. 15
Q.3 a. What are merits and demerits of Wagner-Nelson method in computing Ka? 5
b. What is flip-flop phenomenon and when is it observed? 5
c. Elaborate the type of compartmental models. Why catenary model is less useful then
mammillary model? 5
Q.4 a. What are various types of bioequivalence studies? 8
b. State the plateau principle. Which parameters govern attainment of steady-state? 7
Q.5 Write short notes on the following :
a. Discuss the pharmacokinetics of modified-release drug products. 8
b. What are the various compendial dissolution apparatus designs? Discuss briefly
stating their applications. 7
Q.6 Discuss the following with suitable examples :
a. Statistical moments theory. 5
b. Cross over & carry over study design . 5
c. Plasma half life (t
1/2
), AUC & AUMC. 5
NOTE : Disclosure of Identity by writing Mobile No. or Making of passing request on any
page of Answer Sheet will lead to UMC against the Student.
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This post was last modified on 07 December 2019