Download PTU (Punjab Technical University) M-Pharma (Master of Pharmacy) 1st Semester 74665 ADVANCED MEDICINAL CHEMISTRY Last 10 Years 2020, 2019, 2018, 2017, 2016, 2015, 2014, 2013, 2012, 2011 and 2010 Previous Question Papers.
Roll No. Total No. of Pages : 1
Total No. of Questions : 06
M.Pharma(Pharmaceutical Chemistry) ( 2017 & Onwards) (Sem.?1)
ADVANCED MEDICINAL CHEMISTRY
Subject Code : MPC-103T
M.Code : 74665
Time : 3 Hrs. Max. Marks: 75
INSTRUCTIONS TO CANDIDATES :
1. Attempt any FIVE questions out of SIX questions.
2. Each question carries FIFTEEN marks.
Q1. i) What are the various stages in drug discovery? Elaborate. (9)
ii) What is the difference between an agonist and antagonist? Give examples. (6)
Q2. i) What are the various causes of drug resistance? Discuss the various approaches towards
combating drug resistance to antibiotics. (9)
ii) Discuss briefly any two strategies of analog design. (6)
Q3. i) Discuss the chemistry of angiotensin II antagonists employed in therapy. (9)
ii) What are atypical antipsychotics? Discuss the chemistry of this class of drugs. (6)
Q4. Write short notes on :
i) Anticholinesterases in therapy (5)
ii) Prodrug approach (5)
iii) Prostaglandins and their importance (5)
Q5. i) Discuss the various types of enzyme inhibitors in medicine. Give one example each
(with mechanism) of covalently- and non-covalently binding enzyme inhibitors. (8)
ii) Give a brief account of adrenergic agents in therapy. (7)
Q6. i) Giving specific examples, explain the importance of chirality in drugs. (7)
ii) What are the advantages and therapeutic importance of selective COX-2 inhibitors?
Give chemical structures of important therapeutic drugs from this category . (8)
NOTE : Disclosure of Identity by writing Mobile No. or Making of passing request on any
page of Answer Sheet will lead to UMC against the Student.
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This post was last modified on 07 December 2019