Download University of Jaffna, Sri Lanka B.Pharma 4th Year 2015 July 4201 Advanced Pharmaceutics Question Paper

Download University of Jaffna, Sri Lanka (University of Sri Lanka,) B.Pharma (Bachelor of Pharmacy) Fourth Year (4th Year) 2015 July 4201 Advanced Pharmaceutics Last 10 Years 2020, 2019, 2018, 2017, 2016, 2015, 2014, 2013, 2012, 2011 and 2010 Previous Question Papers.

UNIVERSITY OF JAFFNA
BACHELOR OF PHARMACY
FOURTH YEAR SECOND SEMESTER EXAMINATION ? JULY 2015
PHAAP 4201 ADVANCED PHARMACEUTICS ? PAPER
Date: 07.07.2015. Time:
ANSWER TO ALL SIX QUESTIONS
II
02 Hours
1.
1.1 Briefly describe the pH partition theory for the transport of
drugs across biological membrane. (50 Marks)
1.2 Write a note on pilot pharmaceutical plant scale up technique. (50 Marks)
2.
2.1 What are the storage conditions for various durations for the
stability studies of drugs according to ICH guidelines? (30 Marks)
2.2 Explain how bioavailability of drugs are affected by
2.2.1. presystemic metabolism. (30 Marks)
2.2.2. excipients present in the dosage form (40 Marks)
3.
3.1 What is mixed function oxidase? (10 Marks)
3.2 Give five examples for the oxidative metabolism of drugs. (30 Marks)
3.3 Explain the role of chemical factors in the biotransformation of
drugs. (60 Marks)
4. Write an account on
4.1 common ingredients used in the face powder. (50 Marks)
4.2 moisturizer. (50 Marks)
5.
5.1 Describe the importance of solubility analysis in the
preformulation studies. (40 Marks)
5.2 Explain the role of lubricants in the tablet formulations. (40 Marks)
5.3 List five materials used as plastic packaging. (20 Marks)
6.
6.1 Briefly describe the degradation of drugs by oxidation and
hydrolysis during storage with examples. (70 Marks)
6.2 List the degradation pathways of drugs during storage other
than oxidation and hydrolysis. (30 Marks)
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