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UNIVERSITY OF JAFFNA
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BACHELOR OF PHARMACY
FOURTH YEAR SECOND SEMESTER EXAMINATION — JULY 2015
PHAAP 4201 ADVANCED PHARMACEUTICS - PAPER II
Date: 07.07.2015. Time: 02 Hours
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ANSWER TO ALL SIX QUESTIONS
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- Briefly describe the pH partition theory for the transport of drugs across biological membrane. (50 Marks)
- Write a note on pilot pharmaceutical plant scale up technique. (50 Marks)
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- What are the storage conditions for various durations for the stability studies of drugs according to ICH guidelines? (30 Marks)
- Explain how bioavailability of drugs are affected by
- presystemic metabolism. (30 Marks)
- excipients present in the dosage form (40 Marks)
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- What is mixed function oxidase? (10 Marks)
- Give five examples for the oxidative metabolism of drugs. (30 Marks)
- Explain the role of chemical factors in the biotransformation of drugs. (60 Marks)
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- Write an account on
- common ingredients used in the face powder. (50 Marks)
- moisturizer. (50 Marks)
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- Describe the importance of solubility analysis in the preformulation studies. (40 Marks)
- Explain the role of lubricants in the tablet formulations. (40 Marks)
- List five materials used as plastic packaging. (20 Marks)
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- Briefly describe the degradation of drugs by oxidation and hydrolysis during storage with examples. (70 Marks)
- List the degradation pathways of drugs during storage other than oxidation and hydrolysis. (30 Marks)
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