Download SGBAU BSc 2019 Summer 6th Sem Biochemistry Immunology n Clinical Biochemistry Question Paper

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B.Sc. (Part-III) Semester-VI Examination

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6S : BIOCHEMISTRY
(Immunology and Clinical Biochemistry)

Time : Three Hours] [Maximum Marks : 80

Note :—

1. (A) All questions are compulsory and carry equal marks except question no. 1 which carries 8 marks.

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2. (B) Draw a neat labelled diagram wherever necessary.

1. (A) Fill in the blanks :
   1. The most abundant immunoglobulin in plasma is __________
   2. An immunoglobulin found in external secretions is __________
   3. Immunoglobulins are secreted by __________
   4. The portion of the antigen molecule which is recognised by antibody is known as __________

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2. (B) Choose the correct alternative :
   1. Normal range of serum creatinine is :
      (A) 0.6 — 1.5 mg/dl (B) 9 — 11 mg/dl
      (C) 20 — 25 mg/dl (D) 30 — 35 mg/dl
   2. In the fasting adult, the sugar in CSF is :
      

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      (A) 15 — 45 mg/dl (B) 45 — 80 mg/dl
      (C) 70 — 110 mg/dl (D) 80 — 120 mg/dl
   3. Tumor marker enzyme in prostate cancer is :
      (A) Alkaline phosphatase (B) Acid phosphatase
      (C) CPK (D) LDH

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   4. Which preservative is added to urine to be used for biochemical analysis ?
      (A) HCI (B) Toluene
      (C) Thymol (D) All of the above
3. (C) Answer in one sentence :
   1. Define Acid.

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   2. Define Thermodynamics.
   3. Define Diffusion.
   4. Define Antibody.

1. (a) Explain in brief classification of immunity. (4)
   

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   (b) Describe the structure of IgG. (4)
   (c) Comment on component of cellular immunity. (4)
   OR
   Describe structure and properties of IgA.
   

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2. (a) Explain properties and functions of IgG.
   (b) Explain in brief activation B-cells.
   (c) Explain principle of RIA.
   OR
   (p) Describe mechanism of precipitation.
   

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   (q) Explain complement fixation.
   (r) Write about applications of agglutinations.
   (s) Describe applications of ELISA.
   (t) Write about toxin-antitoxin reaction.
   

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3. Describe in detail mechanism of Type-I and Type-II hypersensitivity with examples.
   OR
   Describe in detail hybridoma technology.
4. (a) Explain with example the concept of molarity and molality.
   (b) Describe quality control in clinical laboratory.
   

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   (c) Explain in brief role of Clinical Biochemistry in diagnosis.
   OR
   (p) Give difference between manual and automation in Clinical Biochemistry.
   (q) Describe different units and abbreviations used in Clinical Biochemistry.
   (r) Discuss the significance of autoanalyzer in Clinical Laboratory.

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5. Describe in detail collection and preservation of biological fluids.
   OR
   Describe in detail chemical analysis of blood and urine.
6. (a) Describe causes and types of albinism.
   (b) Comment on diagnostic applications of SGOT and SGPT.
   

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   (c) Explain with example plasma functional and non-functional enzymes.
   OR
   (p) Write about hyperglycemia.
   (q) Describe isoenzymes of LDH.
   (r) Comment on diagnostic applications of acid phosphatase.

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