Download PTU B-Tech Bio Technology 2020 Dec 5th Sem 70506 Bioinformatics Question Paper

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Roll No. Total No. of Pages : 02

Total No. of Questions : 18

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B.Tech. (BT) (2012 to 2017) (Sem.-5)

BIOINFORMATICS

Subject Code : BTBT-505

M.Code : 70506

Time : 3 Hrs. Max. Marks : 60

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INSTRUCTIONS TO CANDIDATES :

1. SECTION-A is COMPULSORY consisting of TEN questions carrying TWO marks each.
2. SECTION-B contains FIVE questions carrying FIVE marks each and students have to attempt any FOUR questions.
3. SECTION-C contains THREE questions carrying TEN marks each and students have to attempt any TWO questions.

SECTION-A

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Answer briefly :

1. NCBI
2. Sequin
3. PRINTS
4. PHI-BLAST

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5. SWISS-PROT
6. Jukes-Cantor model
7. MMDB
8. Neighbor-Joining method
9. Scop

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10. Ramachandran plot

SECTION-B

Briefly describe any three secondary protein databases.

Briefly describe about PDB.

What are PAM and BLOSUM matrices? Describe their importance.

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What are molecular markers? Write a note on Rasmol.

What is T-COFFEE? Describe about its approach in multiple sequence alignment.

SECTION-C

Describe the prediction of protein structure by using threading method.

Describe various methods used in phylogenetic tree constructions and their importance.

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Align the following sequences by using Smith and Waterman algorithm.

seq 1: ATTCGATCC, seq 2: ACGAT (Use +1 for match and -2 for mismatch and -3 for gap penalty).

NOTE : Disclosure of Identity by writing Mobile No. or Making of passing request on any page of Answer Sheet will lead to UMC against the Student.