Download DM 2020 D.M. (Clinical Haematology) 161404 Recent Advances in Haematology Question Paper

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(LQ 067) FEBRUARY 2020 Sub. Code: 1404

D.M. ? CLINICAL HAEMATOLOGY
Paper IV ? RECENT ADVANCES IN HAEMATOLOGY
Q.P. Code: 161404

Time: Three Hours Maximum: 100 Marks

I. Elaborate on: (2 x 15 = 30)

1. Discuss the recent changes in the WHO 2016 criteria for diagnosis of
myeloproliferative neoplasms.

2. Discuss the diagnosis and relevance of Philadelphia like acute
lymphoblastic leukemia. Also discuss potential strategies to treat these
conditions.

II. Write notes on: (10 x 7 = 70)

1. Anti-Leukemia Activity of the Selective BCL-2 Inhibitor ABT-199.
2. Role of hypo-methylating agents in high risk young adults with acute
myeloid leukemia.
3. Thrombopoeitin receptor agonists and aplastic anemia.
4. Liposomal CPX-351 in acute myeloid leukemia.
5. Targeting microenvironment in leukemia.
6. Artesunate in the management of cytomegalovirus infection.
7. Gene editing strategies.
8. Potential role of Pioglitazone in the management of chronic myeloid
leukemia.
9. Potential role and rationale of IL2 in management of acute graft versus
host disease.
10. Nontransplant therapy in aplastic anemia.


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