Download DNB 2019 June SURGICAL ONCOLOGY SURGICAL ONCOLOGY PAPER 1 Question Paper

Download Diplomate in National Board (DNB) 2019 June SURGICAL ONCOLOGY SURGICAL ONCOLOGY PAPER 1 Previous Question Papers

FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
JUNE 2019
SURGICAL ONCOLOGY
PAPER-l
Time: 3 hours SURG.ONCO/J/19/47/I
Max. Marksz100
Important Instructions:
. Attempt all questions in order.
Each question carries 10 marks.
Read the question carefully and answer to the point neatly and legib/y.
Do not leave any blank pages between two answers.
Indicate the question number correctly for the answer in the margin space.
Answer all the parts of a single question together.
Start the answer to a question on a fresh page or leave adequate space between two answers.
. Draw table/diagrams/f/owcharts wherever appropriate.
Write short notes on:
1. a) Name the types of bias in screening. 1+(3+3+3)
b) Name the available methods used to screen for the
following cancers and briefly mention their advantages and
disadvantages:
i. Cervix cancer
ii. Breastcancer
iii. Colon cancer
2. a) What are the principles of concurrent chemoradiation? 3+2+3+2
b) What is a radiation sensitizer?
c) Mention some chemotherapeutic agents used as radiation
sensitizers and describe their mechanism of action.
d) Mention some molecular targeted drugs which act as
radiation sensitizers and their mechanism of action.
3. a) What are the principles of immunotherapy for cancer? 3+4+3
b) Describe in detail any two approaches used for
immunotherapy of cancers in general.
c) Mention three immune check point modulators and their
therapeutic indications.
4. a) What are DNA adducts? 2+2+6
b) What are the cellular responses to DNA adduct formation?
c) Name three chemotherapeutic drugs which forms DNA
adducts, the malignancies they are commonly used in and
their toxicity profile.
5. a) RECIST criteria for assessing treatment response and its 6+4
modifications.
b) Name three pathological response assessment criteria and
describe any one.
P.T.O.
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POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE EXAMINATION HALL.

FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
JUNE 2019
SURGICAL ONCOLOGY
PAPER-I
6. a) What is next generation sequencing(NGS)? 2+3+3+2
b) Describe its clinical uses.
c) Mention some other methods of gene sequencing.
d) What are the advantages of NGS over polymerase chain
reaction (PCR)?
7. A 35-year old man with two children and no family history of 2+4+4
cancer is diagnosed to have more than 100 polyps throughout
the colorectum on colonoscopy.
a) What is the likely diagnosis and associated clinical
conditions of this syndrome?
b) Describe in brief the molecular pathogenesis of this
condition and how will you confirm the molecular diagnosis.
c) How will you screen and if necessary, treat the children of
this person?
8. a) Clinical anatomy of the pelvic autonomic nerves relevant to 5+5
surgery for rectal cancers.
b) What are the areas at risk for autonomic nerve injury during
rectal cancer surgery and what are the precautions you will
take to avoid such injury?
9. a) How do you calculate survival in clinical trials? 4+4+2
b) Draw a sample Kaplan Meier Survival Curve.
c) What is the use of censoring the data?
10. a) How do you manage a 25-year-old lady presenting with 6+4
right thyroid nodule 2x2cm size, with no palpable lymph
nodes in the neck and an FNAC report of papillary
carcinoma thyroid?
b) What is her prognosis, calculated using a prognostic
scoring system of your choice?
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POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE EXAMINATION HALL.