Download DNB 2019 June MICROBIOLOGY MICROBIOLOGY PAPER 4 Question Paper

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FINAL EXAM
JUNE 2019

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Important Instructions:

• Attempt all questions in order.

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• Each question carries 10 marks.
• Read the question carefully and answer to the point neatly and legibly.
• Do not leave any blank pages between two answers.
• Indicate the question number correctly for the answer in the margin space.
• Answer all the parts of a single question together.

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• Start the answer to a question on a fresh page or leave adequate space between two answers.
• Draw table/diagrams/flowcharts wherever appropriate.

Write short notes on:

1. a) Define multiple drug resistant (MDR) bacteria. 3+7
   b) Role of active surveillance culture in prevention of hospital acquired infections caused by MDR pathogens.

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2. a) Enumerate the non-antibiotic alternatives to treat bacterial infections. 4+6
   b) Current status of bacteriophage therapy in management of bacterial infections.
3. a) Whole genome sequencing. 3+2+
   b) RIBA.
   c) Tuberculosis vaccines.
   

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   d) Inhaled antibiotics for Gram negative respiratory infections.
4. Define outbreak, epidemic and pandemic. Give an outline of the role of a clinical microbiologist in management of an infectious disease outbreak. 3+7
5. a) Define taxonomy. 3+7
   b) Advantages and disadvantages of molecular taxonomy.
6. Define reverse vaccinology. Give an outline of reverse vaccinology technique with example. 3+7

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7. a) Define pre-emptive, empiric and prophylactic antibiotic therapy. 3+7
   b) Principles of prophylactic antibiotic therapy in prevention of surgical site infections.
8. a) Enumerate the molecular epidemiological typing methods for bacteria. 4+6
   b) Parameters to evaluate efficacy of a typing method.
9. CRISPR-Cas system and enlist the applications of the CRISPR-Cas technology in biomedical science. 5+5

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10. a) Enumerate the uses of animal models in infectious disease research. 4+6
    b) Invertebrate models currently used in infectious disease research.

POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE EXAMINATION HALL.