Download DNB 2019 Dec 2019 Dec BIOCHEMISTRY PAPER I Question Paper

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FINAL EXAM

DECEMBER 2019

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BIOCHEMISTRY

PAPER-I

Time: 3 hours BCHEM/D/19/03/1 Max. Marks: 100

Important Instructions:

• Attempt all questions in order.
• Each question carries 10 marks.
• Read the question carefully and answer to the point neatly and legibly.

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• Do not leave any blank pages between two answers.
• Indicate the question number correctly for the answer in the margin space.
• Answer all the parts of a single question together.
• Start the answer to a question on a fresh page or leave adequate space between two answers.
• Draw table/diagrams/flowcharts wherever appropriate.

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1. Write short notes on:
   1. Iso-electric focusing.
   2. Polyacrylamide Gel Electrophoresis.
2. Give the norms of the lymphoid tissues distributed throughout the body. Explain how macrophages amplify a local inflammatory response. 5+5
3. Biochemical changes/findings on investigation of blood and urine in: 2.5x4
   1. Addison’s disease.

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   2. Cushing’s syndrome.
   3. Essential primary Aldosteronism.
   4. Pheochromocytoma.
4. Describe Paper chromatography with its applications. How is TLC (Thin Layer Chromatography) Technique superior to paper chromatography? 4+6

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5. List various liver tests performed in blood and urine in clinical biochemistry laboratories. Explain how these tests help in differentiating in the diagnosis of Hepatocellular Jaundice and Obstructive Jaundice. 6+4
6. 1. Radio Immunoassay.
   2. Is RIA superior to spectrophotometry in analysis of blood hormones and vitamins, if so how? Explain.
   6+4
7. Explain viral etiology of cancer with examples. Add a note on blood and urinary protein or enzymes useful for the diagnosis of cancer. 5+5

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8. Describe the biochemical tests used for assessment of glomerular and tubular functions. How does Cystatin-C help in this assessment? 4+6
9. Discuss tests used to estimate increased risk of cardiovascular disease. Explain the importance of troponin estimation in diagnosis of acute myocardial infarction. 6+4
10. Give therapeutic applications of radioisotopes and diagnostic applications of radioisotopes. 5+5

POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE EXAMINATION HALL.

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