Download DNB 2019 Dec 2019 Dec BIOCHEMISTRY PAPER III Question Paper

Download Diplomate in National Board (DNB) 2019 Dec 2019 Dec BIOCHEMISTRY PAPER III Previous Question Papers

FINAL EXAM
DECEMBER 2019
Time: 3 hours
BIOCHEMISTRY
PAPER-lll
Max. Marksz100
Important Instructions:
I 0 O O D O O
Attempt all questions in order.
Each question carries 10 marks
Read the question carefully and answer to the point neatly and legib/y,
Do not lea ve any blank pages between two answers.
Indicate the question number correctly for the answer in the margin space.
Answer all the parts of a single question together.
NATIONAL BOARD OF EXAMINATIONS
BCHEM/D/19/03/lll
Start the answer to a question on a fresh page or leave adequate space between two answers.
Draw tab/e/diegrams/f/owcharts wherever appropriate.
Write short notes on:
1.
10.
What is Cell mediated immunity and Humoral immunity? What are
paraproteins? Write its Clinical significance.
a) Biochemical effects of tumour growth.
b) Consequences of cancer treatment.
Enumerate the causes of DNA damage and repair mechanisms. What
are clinical significance/manifestations of defective DNA repair
mechanisms?
What is the effect on the Lactose operon of a mutation that inactivates
adenylate cyclase? Add a note on Mobile DNA elements.
Enlist the different types of ROS (Reactive oxygen species) affecting
human health. How are they generated/produced? Enumerate three
enzymes acting/combating as scavengers.
a) What are Proto-oncogenes and oncogenes with examples?
b) Mention important growth factors.
0) List three commonly used Tumor markers and its clinical uses.
Describe cloning of human DNA in bacteria using Recombinant DNA
technology. Briefly describe about DNA library.
What is Restriction Fragment Length Polymorphism (RFLP)? Write a
note on Gene therapy and its applications.
Describe autoimmune disorders. What is the role of Immune system in
organ transplantation?
a) Chaperons.
b) HSPs (Heat Shock Proteins).
0) Protein Targeting.
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