FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2016
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BIOCHEMISTRY
PAPER - II
BIO/D/16/03/11
Time : 3 hours
Max. Marks :100
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Important instructions:
- Attempt all questions in order.
- Each question carries 10 marks.
- Read the question carefully and answer to the point neatly and legibly.
- Do not leave any blank pages between two answers.
- Indicate the question number correctly for the answer in the margin space.
- Answer all the parts of a single question together.
- Start the answer to a question on a fresh page or leave adequate space between two answers.
- Draw table/diagrams/flowcharts wherever appropriate.
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Write short notes on:
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- a) “Glucose+Pi —glucose 6 phosphate”. 5+5
“Dihydroxyacetone phosphate —glyceraldehyde 3 phosphate”.
The above two reactions are thermodynamically unfavorable (i.e. AGy
is +ve), but yet they occur in human body. Explain how?
b) Write the functional/physiological significance and reactions catalysed--- Content provided by FirstRanker.com ---
by protein kinases. - a) How can it be proved that both electrical and concentration gradient 5+5
of proton across inner mitochondrial membrane is required to drive
ATP synthetase (FoF1 particle)?
b) Explain the impact on ATP synthesis from FADH2 by oxidative--- Content provided by FirstRanker.com ---
phosphorylation when following chemical individually is added to
mitochondrial suspension:
i) Cyanide
ii) Amobarbital
i) Carboxine--- Content provided by FirstRanker.com ---
iv) Oligomycin and
v) 2,4 dinitrophenol - a) Define ‘Body mass index’ and obesity. Write the role of gut, adipose 5+5
tissue and hypothalamus in calorie homeostasis.
b) Biochemical basis (pathogenesis) of beta cell dysfunction in diabetes--- Content provided by FirstRanker.com ---
mellitus. - a) Write the role of vitamin A in photoactivation of rhodopsin. 5+5
b) How does photoactivation of rhodopsin cause hyperpolarization of rod
cells? - a) List the chemicals having vitamin K activity. 3+6+1
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b) Mechanism of action of vitamin K.
¢) Indicate which step of vitamin K cycle is blocked by warfarin. - a) List ultra-trace elements. 2+8
b) Functions and clinical importance of ultra-trace elements. - a) List the substances (chemical names) that act as soluble and 3+7
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insoluble dietary fibre.
b) How does the use of dietary fibres lead to primary and secondary
prevention of diseases? - How can primary, secondary and tertiary thyroid dysfunctions be 10
differentiated by using laboratory tests? - a) Define classl, Il and Il prostanoids. 1+6+3
b) How are they synthesized?
c) Explain how different drugs that can inhibit their synthesis. - a) How is HDL metabolized? 5+2+3
b) Write its function(s).--- Content provided by FirstRanker.com ---
c) How can HDL-cholesterol level in blood be increased by different
therapeutic means?
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