Download DNB 2016 Dec RADIOTHERAPY PAPER 3 Question Paper

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FINAL EXAM NATIONAL BOARD OF EXAMINATIONS

DECEMBER 2016

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RADIOTHERAPY

PAPER - III

Time : 3 hours

Max. Marks : 100

Important instructions:

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• Attempt all questions in order.
• Each question carries 10 marks.
• Read the question carefully and answer to the point neatly and legibly.
• Do not leave any blank pages between two answers.
• Indicate the question number correctly for the answer in the margin space.

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• Answer all the parts of a single question together.
• Start the answer to a question on a fresh page or leave adequate space between two answers.
• Draw table/diagrams/flowcharts wherever appropriate.

Write short notes on:

1. a) Name four situations which require modification of doses of anti-neoplastic chemotherapy. 2+(4+4)
   

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   b) Indications, mechanism of action & side effects of:
   i) Carboplatin
   ii) Sorafenib
2. a) What is EGFR? 2+2+6
   b) Name the malignancies that are associated with the over-expression of EGFR.
   

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   c) Explain the role of EGFR targeting in three common cancers.
3. a) Name the tumours arising from metaphysis and diaphysis. 2+(2+2+2)+2
   b) Role of the following imaging in Ewing’s sarcoma:
   i) Plain X-ray,
   ii) MRI scan
   

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   iii) PET-CT scan
   c) Immunohistochemistry tests in histopathologic diagnosis of Ewing’s sarcoma.
4. a) Name the features associated with a known genetic predisposition to breast carcinoma. 2+3+5
   b) Enumerate the components of risk/benefit assessment and counseling in breast cancer risk reduction.
   c) Define cancer related fatigue, its evaluation and management.

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5. a) What are the viral infections associated with CNS lymphoma? 2+4+4
   b) Staging work up of CNS lymphoma
   c) Evidence for multimodality treatment and its benefit over radiotherapy alone.
6. a) What are the non-malignant intracranial lesions treated with radiotherapy? 5+5
   b) Radiotherapy technique and dose of thyroid ophthalmopathy.

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7. a) A 50 year old lady has a newly diagnosed esophageal cancer extending from 30 to 35cm (GE junction at 40 cm). What is the role of endoscopic ultrasound and PET-CT Scan in this patient? 4+6
   b) Treatment algorithm in the management of the patient.
8. Transarterial chemo-embolisation: Selection criteria, indications, contraindications & side effects. 2.5x4
9. a) Role of radiotherapy in small cell carcinoma lung. 4+4+2
   b) Technique of radiotherapy and doses in small cell carcinoma lung, and
   

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   c) Tolerance doses of organs at risk.
10. a) Partial breast irradiation: Rationale, Techniques & results. 6+4
    b) Molecular and genetic characteristics of Glioblastoma Multiforme with regards to:
    i) Prognosis
    ii) Management

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