Download RTMNU B.Pharma 4th Semester 2017 Summer Pharmaceutical Chemistry 4 (Heterocyclic And Macromolecules) Question Paper

Download RTMNU (Rashtrasant Tukadoji Maharaj Nagpur University) B.Pharma (Bachelor of Pharmacy) 4th Semester 2017 Summer Pharmaceutical Chemistry 4 (Heterocyclic And Macromolecules) Question Paper

NKT/KS/17/6559
B.Pharm (Fourth Semester) (C.B.S.) Examination
PHARMACEUTICAL CHEMISTRY?IV
(Heterocyclic And Macromolecules)
Paper?Z
Time : Three Hours] [Maximum Marks : 80
NB. :? (1) Question n0. 1 is compulsory.
(2) Solve any four questions from remaining.
(3) Assume suitable data wherever necessary.
(4) Discuss the reaction, mechanism wherever necessary.
1. Solve any ?ve of the following : 4X5=20
(a) Pyrimidine undergoes electrophilic substitution at 5?positi0n only. Why ?
(b) Why pyridine is more basic than pyrrole ?
(0) Write a note on mutarotation.
(d) Draw the structures of maltose, salicin.
(e) Give Bischler-Napieralski reaction of Isoquinoline.
(1) Write the chemical properties of thiophene.
(g) De?ne acid value and saponi?cation value with its signi?cance.
2. (a) What are lipids ? Explain in brief about phospholipids. 8
(b) Discuss the various chemical constants used for evaluation of oil. 7
3. (a) What are proteins ? Give their classi?cation. How will you determine secondary structure of
protein ? 8
(b) Discuss various methods used for determination of C?terminal amino acid residue in
protein/polypeptide. 7
4. De?ne polynuclear aromatic hydrocarbon and classify it with structure. Discuss the structure, synthesis
and chemical reactions of Anthracene. 15
5. Define and classify carbohydrate giving suitable examples with structures. Explain in brief
Killiani?Fischer synthesis, Wohl?s degradation and Ruffs degradation method of carbohydrate.
15
NXO?20308 1 (Contd)

6. (a) De?ne and classify amino acid with structures. Discuss isolation and puri?cation of amino acids
from protein mixture. 8
(b) Discuss osazone formation and Glycoside formation of monosaccharides. 7
7. Solve any three :
(a) Skraup?s Quinoline synthesis
(b) Chichibabin reaction
(c) Fischer?Indole synthesis
((1) Haworth synthesis of Naphthalene
(6) Structure chemistry and importance of phenothiazine. 5X3=15
NXO?20308 2 NKTKS/17/6559