Download RTMNU B.Pharma 5th Semester 2016 Winter Pharmaceutical Medicinal Chemistry 1 Question Paper

KNT/KW/16/6565

B.Pharm. Fifth Semester (C.B.S.) Examination

PHARMACEUTICAL MEDICINAL CHEMISTRY—І

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Paper-2 (52)

[Full Marks: 80

N.B. :— (1) Question No. 1 is compulsory.

(2) Attempt any FOUR questions from remaining.

(3) Draw neat labeled diagram wherever necessary.

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(4) Discuss the reaction, mechanism wherever necessary.

1. Solve any FIVE of the following :
   1. Write chemical classification of NSAIDs with suitable examples.
   2. Give general rules for nomenclature of prostaglandins.
   3. Classify antitussives with suitable examples. How will you prepare caramiphen ?
   4. Justify citing suitable examples, how drug metabolism studies can be useful in drug development.

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   5. Enumerate the ideal properties of prodrugs.
   6. Why benserazide is given in combination of levodopa to treat Parkinson's disease ?
   7. Write about various stages of analgesia.

   5×4=20

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2. Discuss the chemistry and activity of oral hypoglycemic agents. Outline synthesis of glipizide.

   15

3. 1. What is bioisosterism ? How is it useful in design of drugs ?
   2. Explain the role of pka in the biological activity of drugs.

   8

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   7

4. What are local anaesthetics ? Classify them with suitable examples. Discuss the SAR of benzoic acid as local anaesthetics. Outline synthesis of orthocaine and xylocaine.

   15

5. 1. What are antihistamines ? Write the difference between H₁ receptor blockers and H₂ receptor blockers.

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   2. What principles are utilized in prodrug design for taste masking and odour improvement of drug ? Justify with suitable examples.

   7

   8

6. 1. Explain chemistry of barbiturates as sedative and hypnotics. Outline synthesis of thiopental sodium.

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   2. Write the SAR of tricyclic antidepressant drugs. Write synthesis of amitryptilene.

   7

   8

7. Write short notes on any THREE of the following :—
   1. Bronchodilators

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   2. Hydantoins
   3. Thyroid and antithyroid drugs
   4. Glucuronidation
   5. Morphine.

   15

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