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B.Pharm. Seventh Semester (C.B.S.) Examination
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BIOPHARMACEUTICS AND PHARMACOKINETICS
Paper-6
NKT/KS/17/6581
Time: Three Hours]
[Maximum Marks : 80
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N.B. :— (1) Question No. 1 is compulsory.
(2) Attempt any FOUR questions from remaining.
(3) Draw neat labelled diagram wherever necessary.
(4) Discuss the reaction, mechanism wherever necessary.
(5) Use of electronic calculator, excluding programmable calculator is permitted.
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- Solve any FIVE questions : 5×4=20
- What is first pass effect ?
- What is the relationship between apparent volume of distribution with clearance ?
- Enumerate the objectives of bioavailability studies and explain the term absolute and relative bioavailability.
- What are the various causes of nonlinearity of drugs?
- What is IVIVC ?
- Describe Hixon Crowell's model for erodible matrix formulations.
- What do you understand by tissue localization of drugs?
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- (a) Describe the various physiological barriers affecting distribution of drug. 8
(b) Discuss the significance of protein bindings of drug. 7 - Discuss in detail about phase I biotransformation of drug. 15
- (a) Describe the principal processes that determine the urinary excretion of a drug. 8
(b) Describe the factors affecting renal clearance of drugs. 7 - (a) Describe the various methods of assessment of bioavailability. 8
(b) Describe the various transport mechanisms in absorption of drug. 7 - Discuss the one compartment open model for IV Bolus and IV Infusion administration. 15
- Write a short note (any THREE) : 3×5=15
- Theory of dissolution
- Kinetics of protein drug binding
- Gastric Emptying
- Plasma Drug Concentration Profile.
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NXO-12551
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