Download RTMNU B.Pharma 7th Semester 2017 Summer Biopharmaceutics and Pharmacokinetics Question Paper

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B.Pharm. Seventh Semester (C.B.S.) Examination

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BIOPHARMACEUTICS AND PHARMACOKINETICS

Paper-6

NKT/KS/17/6581

Time: Three Hours]

[Maximum Marks : 80

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N.B. :— (1) Question No. 1 is compulsory.

(2) Attempt any FOUR questions from remaining.

(3) Draw neat labelled diagram wherever necessary.

(4) Discuss the reaction, mechanism wherever necessary.

(5) Use of electronic calculator, excluding programmable calculator is permitted.

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1. Solve any FIVE questions : 5×4=20
   1. What is first pass effect ?
   2. What is the relationship between apparent volume of distribution with clearance ?
   3. Enumerate the objectives of bioavailability studies and explain the term absolute and relative bioavailability.
   4. What are the various causes of nonlinearity of drugs?
   5. What is IVIVC ?

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   6. Describe Hixon Crowell's model for erodible matrix formulations.
   7. What do you understand by tissue localization of drugs?
2. (a) Describe the various physiological barriers affecting distribution of drug. 8
   (b) Discuss the significance of protein bindings of drug. 7

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3. Discuss in detail about phase I biotransformation of drug. 15
4. (a) Describe the principal processes that determine the urinary excretion of a drug. 8
   (b) Describe the factors affecting renal clearance of drugs. 7
5. (a) Describe the various methods of assessment of bioavailability. 8
   (b) Describe the various transport mechanisms in absorption of drug. 7

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6. Discuss the one compartment open model for IV Bolus and IV Infusion administration. 15
7. Write a short note (any THREE) : 3×5=15
   1. Theory of dissolution
   2. Kinetics of protein drug binding
   3. Gastric Emptying
   4. Plasma Drug Concentration Profile.

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