Download RTMNU B.Pharma 2nd Semester 2016 Summer Pharmaceutical Chemistry 2 (Organic) Question Paper

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B. Pharm. Semester-II (C.B.S.) Examination

PHARMACEUTICAL CHEMISTRY–II (Organic)

Paper-II (2T2)

Time-Three Hours]

[Maximum Marks—80

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N.B.:- (1) Question No. 1 compulsory.

(2) Solve any FOUR questions from the remaining.

(3) Draw neat labelled diagram wherever necessary.

(4) Use of electronic calculator is permitted.

1. Solve any FIVE of the following :
   1. What is sp hybridization ? Explain with examples.

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   2. What is diastereomers and enantiomers ?
   3. Define empirical formula and molecular formula with examples.
   4. What is sequence rule ?
   5. Give the physical properties of alkyl halides.
   6. Explain Bayer strain theory.

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   7. Give the procedure to detect carboxylic acid.

   20

2. 1. Combustion of 5.17 mg sample of a compound gives 10.32 mg of carbon dioxide and 4.23 mg of water. The molecular weight was found to be 88. Calculate the molecular formula of the compound.

      8

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   2. Describe Dumas method for estimation of Nitrogen in organic compound.

      8

3. 1. Give a brief note on intermolecular forces.

      7

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4. Justify any THREE of the following :
   1. Chair conformation of cyclohexane is most stable.
   2. Nitrogen in ammonia is sp³ hybridized. Justify
   3. Geometric isomers are more separable than enantiomers.
   4. O-Nitrophenol has much lower volatility.

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   7

5. 1. Discuss Pauli's exclusion principle.
   2. Write a note on Lassaigne's test.

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6. 1. Give a brief note on polarity of bonds.

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7. 1. What are different types of organic reactions ? Explain giving one example of each. What are the factors affecting them ?

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   2. Write the structural formula of following :
      1. Anisidine
      2. 1,3 Cyclohexadiene
      3. 2, 2, 4 – trimethyl pentane
      4. tert-Butyl bromide

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      5. 2, 2 – Dimethyl–3 –pentanol.

      5

8. 1. Draw the structural formula and give IUPAC name of the following :
      1. CH3 CH.OH.CH. (CH3)2

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      2. (CH3)2CH · CH2O CH, CH(CH3)2
      3. CH, CH, CH, CO CH
      4. trans (CH3)2 – CH – CH = CH – CH (CH3)2
   2. What is optical activity ? Explain the term specific rotation and means to measure it.

      8

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