Download RTMNU B.Pharma 2nd Semester 2016 Summer Pharmaceutical Chemistry 2 (Organic) Question Paper

Download RTMNU (Rashtrasant Tukadoji Maharaj Nagpur University) B.Pharma (Bachelor of Pharmacy) 2nd Semester 2016 Summer Pharmaceutical Chemistry 2 (Organic) Question Paper

TKN/KS/16/6976
B. Pharm. Semester-II (C.B.S.) Examination
PHARMACEUTICAL CHEMISTRY?II (Organic)
Paper?II (2T2)
Time?Three Hours] [Maximum Marks?80
N.B.:? (1) Question N0. 1 compulsory.
(2) Solve any FOUR questions from the
remaining.
(3) Draw neat labelled diagram wherever
necessary.
(4) Use of electronic calculator is permitted.
1. Solve any FIVE 0f the following :
(a)
(b)
(C)
(d)
(e)
(f)
(5;)
What is sp hybridization ? Explain with examples.
What is diastereomers and enantiomers ?
De?ne empirical formula and molecular formula with
examples.
What is sequence rule ?
Give the physical propeIties of alkyl halides.
Explain Bayer strain theory.
Give the procedme to detect carboxylic acid.
20
MXP?N?37 1 0 1 Contd.

2. (a)
(b)
Combustion of 5.17 mg sample of a compound gives
10.32 mg of carbon dioxide and 4.23 mg of water.
The molecular weight was found to be 88. Calculate
the molecular formula of the compound. 8
Describe Dumas method for estimation of Nitrogen
in organic compound. 7
3. Justify any THREE 0f the following :
(a)
(b)
(C)
(d)
(b)
(b)
Chair conformation of cyclohexane is most stable.
Nitrogen in ammonia is sp3 hybridized. Justify.
Geometric isomers are more separable than
enantiomers.
O?Nitrophenol has much lower volatility. 15
Discuss Pauli's exclusion principle. 8
Write a note on Lassaigne's test. 7
Give a brief note on polarity of bonds. 7
What is optical activity ? Explain the term speci?c
rotation and means to measure it. 8
Draw the structural fonnula and give IUPAC name
of the following :
(1) CH3 ~ CH - OH - CH - (CH3)2
(11) (CH3)2 - CH ~ CHZO CH2 CH - (CH3)2
MXP?N?37 1 0 2 Contd.
(b)
(a)
(b)
(iii) CH3 CH2 CH2 CO CH3
(iv) trans (CH3)2 ? CH ? CH = CH ? CH (CH3)2
8
Give a brief note on intermolecular forces. 7
What are di?erent types of organic reactions ? Explain
giving one example of each. What are the factors
affecting them ? 10
Write the structural formula of following :
(i) O- Anisidine
(ii) 1, 3 ? Cyclohexadiene
(iii) 2, 2, 4 ? trimethyl pentane
(iv) teIt ?Butyl bromide
(V) 2, 2 ? Dimethyl?3 ?pentan01. 5
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