Download RTMNU B.Pharma 3rd Semester 2015 Winter Pharmaceutical Chemistry 3 (Organic) Question Paper

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Faculty of Pharmacy

B.Pharm. Third Semester (C.B.S.) Examination

PHARMACEUTICAL CHEMISTRY—III (ORGANIC)

Paper-II (3T-2)

Time : Three Hours] [Full Marks: 80

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N.B. :— (1) Question No. 1 is compulsory.

(2) Solve any FOUR questions from the remaining.

(3) Draw neat labeled diagram wherever necessary.

1. Solve any FIVE of the following : 5×4=20
   1. Write the mechanism of Hofmann degradation reaction.
   2. Justify that SN 1 reactions are accompanied by rearrangement.

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   3. Explain conformation of n-butane.
   4. Why cyclopropane always undergo ring opening reaction ?
   5. State how heat of hydrogenation proves unusual stability of benzene.
   6. Explain any two reactions of carboxylic acid.
   7. Aldehydes are more reactive than ketone. Explain.

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2. 1. Discuss Aldol condensation with suitable examples. 8
   2. Explain Cannizzarro's reactions with suitable examples. 7
3. Give detailed account of SN² reaction including mechanism, orientation and reactivity. 15

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4. Outline the laboratory synthesis of following from benzene :
   1. p-chloro benzoic acid
   2. p-toluidine
   3. Diphenyl methane
   4. m-bromo phenol
   5. Styrene.

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   15
5. Write in detail about method of preparation of alkenes using suitable examples. 15
6. 1. Elaborate the detailed account of E2 mechanism supporting evidences and sterochemistry. 8
   2. Write a short note on Hinsberg test. 7

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7. Discuss the electrophilic aromatic substitution reaction of benzene with :
   1. Nitration
   2. Sulphonation
   3. Friedel-Craft's alkylation
   4. Friedel-Craft's acylation
   5. Halogenation.

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   15

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