Download RTMNU B.Pharma 3rd Semester 2016 Winter Pharmaceutical Chemistry 3 (Organic) Question Paper

KNT/KW/16/655

B. Pharm. Semester—III (C.B.S.) Examination

PHARMACEUTICAL CHEMISTRY–III (Organic)

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Paper-2

Time : Three Hours] [Full Marks: 80

N.B. :- (1) Question No. 1 is compulsory.

(2) Solve any FOUR questions from the remaining.

(3) Discuss the reaction, mechanism wherever necessary.

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1. Solve any FIVE of the following : 5×4=20
   1. Explain Huckel's rule with suitable examples.
   2. Aldehydes are much more reactive than ketone. Explain.
   3. How will you determine unsaturation of given unknown organic compound.
   4. SN¹ reaction accompanied by rearrangement, justify.
   5. Compare basicity of amines.

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   6. Write a note on peroxide effect.
   7. State and explain any two reactions of carboxylic acids.
2. (a) Discuss Aldol condensation with suitable examples. 5
   (b) Explain in detail, reactions of Phenol. 10

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3. (a) Chlorination of isobutane yields 64% isobutyl chloride and 36% tert. butyl chloride. Explain. 5
   (b) Discuss in detail bimolecular nucleophilic aliphatic substitution reaction. 10
4. Write about methods of preparation of alkene. Give detailed account of E1 reaction covering mechanism, evidences, orientation and stereochemistry. 15
5. (a) Outline the laboratory synthesis of following from benzene (Any TWO) :
   1. m-nitrobenzophenone.
   2. m-bromophenol.

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   3. p-aminobenzoic acid.
   4. p-iodonitrobenzene.
   (b) Enlist various electrophilic aromatic substitution reactions of benzene. Explain the mechanism of nitration reaction of benzene. 8
6. (a) How will you differentiate 1º, 2º and 3º amines ? 7
   (b) Write a concise account on orientation and reactivity of aromatic compounds. 5

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7. Write notes on (any THREE) : 15
   1. Keto-enol tautomerism.
   2. Grignard reagent and its significance.
   3. Acidity of carboxylic acids.
   4. Diazonium salt and its importance.
   5. Hoffmann degradation reaction of amide.

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