Download RTMNU B.Pharma 3rd Semester 2016 Winter Pharmaceutical Chemistry 3 (Organic) Question Paper

KNT/KW/16/655

B. Pharm. Semester—III (C.B.S.) Examination

PHARMACEUTICAL CHEMISTRY–III (Organic)

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Paper-2

Time : Three Hours] [Full Marks: 80

N.B. :- (1) Question No. 1 is compulsory.

(2) Solve any FOUR questions from the remaining.

(3) Discuss the reaction, mechanism wherever necessary.

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1. Solve any FIVE of the following : 5×4=20
   1. Explain Huckel's rule with suitable examples.
   2. Aldehydes are much more reactive than ketone. Explain.
   3. How will you determine unsaturation of given unknown organic compound.
   4. SN¹ reaction accompanied by rearrangement, justify.
   5. Compare basicity of amines.

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   6. Write a note on peroxide effect.
   7. State and explain any two reactions of carboxylic acids.
2. (a) Discuss Aldol condensation with suitable examples. 5
   (b) Explain in detail, reactions of Phenol. 10

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3. (a) Chlorination of isobutane yields 64% isobutyl chloride and 36% tert. butyl chloride. Explain. 5
   (b) Discuss in detail bimolecular nucleophilic aliphatic substitution reaction. 10
4. Write about methods of preparation of alkene. Give detailed account of E₁ reaction covering mechanism, evidences, orientation and stereochemistry. 15
5. (a) Outline the laboratory synthesis of following from benzene (Any TWO) :
   1. m-nitrobenzophenone.
   2. m-bromophenol.

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   3. p-aminobenzoic acid.
   4. p-iodonitrobenzene.
   (b) Enlist various electrophilic aromatic substitution reactions of benzene. Explain the mechanism of nitration reaction of benzene. 8
6. (a) How will you differentiate 1º, 2º and 3º amines ? 7
   (b) Write a concise account on orientation and reactivity of aromatic compounds. 5

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7. Write notes on (any THREE) : 15
   1. Keto-enol tautomerism.
   2. Grignard reagent and its significance.
   3. Acidity of carboxylic acids.
   4. Diazonium salt and its importance.
   5. Hoffmann degradation reaction of amide.

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