Download RTMNU B.Pharma 3rd Semester 2017 Summer Pharmaceutical Chemistry 3 (Organic) Question Paper

B.Pharm. Semester—III (C.B.S.) Examination

PHARMACEUTICAL CHEMISTRY–III (Organic)

Paper-2

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NKT/KS/17/6553

[Maximum Marks : 80

Note :-(1) Question No. 1 is compulsory.

(2) Solve any four questions from remaining.

(3) Discuss the reaction, mechanism wherever necessary.

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1. Solve any five of the following : 4×5=20
   1. Justify giving examples, cyclopropane always undergo ring opening reactions.
   2. What product would you expect when bromine dissolved in carbon tetrachloride reacts with propene in the presence of water ? Write the mechanism for this reaction.
   3. Write a note on hydration of propyne.
   4. Among benzaldehyde and acetaldehyde, which will undergo Cannizzaro reaction and why ?
   5. Write the laboratory tests used for identifying various classes of amines.

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   6. Write a note on α-halogenation of aliphatic acids.
   7. Discuss the reactivity of toluene and nitrobenzene mononitration.
2. 1. Explain the nucleophilic aliphatic substitution reaction which is accompanied with complete inversion of configuration. 9
   2. Give an elaborate account of E₁ mechanism. 6

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3. 1. Explain the mechanism of nucleophilic addition to carbonyl compounds and write some important reactions given by aldehydes and ketone. 8
   2. State and explain the preparation and reactions of phenol. 7
4. 1. Grignard reagent is one of the most versatile reagents in organic chemistry. Justify the statement giving suitable examples. Depict the mechanism involved in the formation of this reagent. 10

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   2. Write the mechanism of cumene hydroperoxide rearrangement. 5
5. How will you plan for the following synthesis from benzene (any five) : 3×5=15
   1. p-toluidine
   2. m-bromophenol
   3. p-amino benzoic acid

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   4. diphenyl methane
   5. picric acid
   6. styrene ?
6. 1. Explain Markonikov's and Anti-markonikov's orientation giving examples and mechanism involved.

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   2. Write a note on halogenation of alkane.
7. Write short notes on (any three) : 5×3=15
   1. Hofmann degradation reaction
   2. Aldol condensation
   3. Reimer-Tiemann reaction

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   4. Pyrolysis and cracking.
8. Give a detailed account of electrophic aromatic substitution reactions covering mechanism, reactivity and orientation. 15

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