B.Pharm.
PHARMACEUTICAL CHEMISTRY–III (Organic)
Paper-2
--- Content provided by FirstRanker.com ---
Time: Three Hours]
[Maximum Marks : 80
N.B. :— (1) Question No. 1 is compulsory.
(2) Attempt any four questions out of remaining.
(3) Discuss the reaction, mechanism wherever necessary.
--- Content provided by FirstRanker.com ---
1. Solve any five of the following : 4×5=20
(a) Benzene gives substitution reaction rather than addition. Justify.
(b) Write about keto-enol tautomerism.
(c) How will you differentiate 1º, 2º and 3° amines ?
(d) Carboxylic acids are stronger acids than phenols, explain.
--- Content provided by FirstRanker.com ---
(e) Explain Satzeff's and Markonikov's rule with suitable example.
(f) Why Carbonyl compounds gives nucleophilic addition reactions ?
(g) Addition of HBr to propene in the presence of peroxide yields n-propyl bromide, Explain.
2. Give a detailed account of electrophilic aromatic substitution reaction including mechanism, reactivity and orientation. 15
3. Depict and discuss the mechanism of following reactions (any three) : 5×3=15
--- Content provided by FirstRanker.com ---
(a) 2 moles of Acetaldehyde + sod.hydroxide ? ?
(b) Propane + Chlorine + UV light ? ?
(c) Benzene + Nitric acid + Sulfuric acid ? ?
(d) Phenol + Chloroform + Aq. NaoH ? ?
(e) Isobutylene + Isobutane + Conc. H2SO4 ?
--- Content provided by FirstRanker.com ---
4. What are Aliphatic nucleophilic substitution reactions ? Discuss in detail SN¹ and SN² reactions. 15
5. How will you plan for the following synthesis, starting from benzene (any three) ? 5×3=15
(a) Phenyl acetic acid
(b) 1-phenyl-azo-2-naphthol
(c) 3-bromo-4-amino toluene
--- Content provided by FirstRanker.com ---
(d) M-nitrobenzophenone
(e) Salicylaldehyde
6. (A) What are organometallic compounds ? Discuss in detail about their preparation and synthetic applications. 10
(B) Enlist the various methods of preparation of aldehydes and ketones. 5
7. Write short notes on any three of the following : 5×3=15
--- Content provided by FirstRanker.com ---
(a) Functional derivatives of carboxylic acids
(b) Benzyl radical and its stability
(c) Hoffman degradation of amides
(d) E2 reaction
(e) Aromaticity.
--- Content provided by FirstRanker.com ---
This download link is referred from the post: RTMNU B-Pharm Last 10 Years 2010-2020 Previous Question Papers || Rashtrasant Tukadoji Maharaj Nagpur University
--- Content provided by FirstRanker.com ---