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B.Pharm. Semester–IV (C.B.S.) Examination
PHARMACEUTICAL CHEMISTRY-IV
(Heterocyclic and Macromolecules)
Paper-2 (4T2)
Time-Three Hours] [Full Marks-80
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N.B. :- (1) Question No. 1 is compulsory.
(2) Solve any FOUR questions from the remaining.
(3) Draw neat labeled diagram wherever necessary.
(4) Discuss the reaction, mechanism wherever necessary.
(5) Assume suitable data wherever necessary.
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1. Solve any FIVE of the following : 4×5=20
(a) Define Saponification Value and Iodine Value with its significance.
(b) Write the biological importance of heterocycles in medicinal chemistry.
(c) Write the chemical properties of Pyrimidine.
(d) Write a note on mutarotation phenomenon in Carbohydrates.
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(e) Pyridine is more basic than Pyrrole. Explain.
(f) Differentiate between fats, oils and waxes.
(g) Why Pyrrole undergoes electrophilic substitution reaction of C-2 position ?
2. (a) What are heterocyclic compounds ? Discuss in detail about chemistry, properties and synthesis of Pyridine. 8
(b) Discuss the reaction and mechanism of Skroup's synthesis of Quinoline. 7
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3. (a) Discuss the structure and synthesis of Naphthalene. 8
(b) Write the chemical properties of Naphthalene. 7
4. (a) Define and classify carbohydrates giving suitable examples with structure. Add a note on cyclic structure of D-glucose. 8
(b) Describe in detail about Killiani-Fischer synthesis and Ruff's degradation method. 7
5. (a) Define and classify Amino acids with suitable structure. Give any one method for amino and carbonyl end degradation of amino acid. 8
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(b) Discuss the secondary structure of proteins. 7
6. (a) Define and classify Lipids. Explain various pharmacopoeial standards to check purity of oil. 8
(b) Write a note on Phospholipids. 7
7. Attempt the following (any THREE) : 15
(a) Fischer-Indole Synthesis
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(b) Chemistry of Maltose
(c) Bischler-Napierolski reaction of Isoquinoline
(d) Chichibabin reaction
(e) Structure of Amygdalin.
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