Download OU M.Pharma Ph.Chemistry 1st Sem 2018 1161PCI Advanced Organic Chemistry I Question Paper

FirstRanker.com
Firstranker's choice
Code No. 1161/PCI

--- Content provided by FirstRanker.com ---

FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutical Chemistry) I-Semester (PCI) (Main) Examination, February 2018
Subject: Advanced Organic Chemistry - |
Time: 3 Hrs Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

--- Content provided by‌ FirstRanker.com ---

1. (a) Explain SN¹ and SN² reactions in aliphatic compounds with their mechanism and stereochemistry.
   (b) Explain how the following factors will affect the reactivity in nucleophilic substitution reactions?
   (i) Substrate structure (ii) Solvent
   (iii) leaving group (iv) attacking nucleophile (8+7)
2. (a) Give a method of preparation, mechanism and applications of
   

   --- Content provided by⁠ FirstRanker.com ---

   (i) N-bromosuccinamide (ii) Diazomethane (iii) DCC (3x3)
   (b) Discuss the stability of carbocations: (6)
3. Discuss the mechanism and synthetic applications of any three of the following named reactions.
   (a) Ugi reaction
   (b) Dieckmann reaction
   

   --- Content provided by‌ FirstRanker.com ---

   (c) Sandmeyer reaction
   (d) Michael addition
   (e) Baeyer-villiger oxidation
4. (a) Explain the role of protecting groups in organic synthesis. Explain how carbonyl, carboxyl and amino groups are protected during the synthesis?
   (b) Mention the heterocyclic nucleus present and also the steps involved in the synthesis of
   

   --- Content provided by FirstRanker.com ---

   (i) Antipyrin (ii) Chlorpromazine (7+8)
5. (a) Explain the following terms with one example each.
   (i) Retrosynthesis
   (ii) Functional group interconversion
   (iii) Functional group addition
   

   --- Content provided by​ FirstRanker.com ---

   (iv) Synthon and synthetic reagent
   (b) Discuss C — X disconnections and C — C disconnections of 1,2-, 1,3 -, 1, 4- and 1, 5 — difunctionalized compounds belonging to alcohols and carbonyl compounds. (8+7)
6. (a) Explain E1 and E2 elimination reactions with their mechanism and stereochemistry.
   (b) Discuss Saytzeff and Hoffman rules. (9+6)
7. (a) Explain the structure, stability and important reactions of carbanions.
   

   --- Content provided by⁠ FirstRanker.com ---

   (b) Discuss mechanism and synthetic applications of following agents:
   (i) Aluminium isopropoxide
   (ii) Wittig reagent (8+7)

--- Content provided by‍ FirstRanker.com ---