Download OU M.Pharma Ph.Chemistry 1st Sem 2018 1161PCI Advanced Organic Chemistry I Question Paper

Download OU (Osmania University) M.Pharma-Ph.Chemistry (Master of Pharmacy) 1st Sem 2018 1161PCI Advanced Organic Chemistry I Previous Question Paper

- 1707 - 1707
Code No. 1161/PCI
FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutical Chemistry) I-Semester (PCI) (Main) Examination,
February 2018
Subject: Advanced Organic Chemistry - I
Time: 3 Hrs Max. Marks: 75
Note: Answer any five questions. All questions carry equal marks.
1 (a) Explain SN
1
and SN
2
reactions in aliphatic compnds with their mechanism
and stereochemistry.
(b) Explain how the following factors will affect the reactivity in nucleophilic
substitution reactions?
(i) Substrate structure (ii) Solvent
(iii) leaving grp (iv) attacking nucleophile (8+7)
2 (a) Give a method of preparation, mechanism and applications of
(i) N-bromosuccinamide (ii) Diazomethane (iii) DCC (3x3)
(b) Discuss the stability of carbocations. (6)
3 Discuss the mechanism and synthetic applications of any three of the
following named reactions.
(a) Ugi reaction
(b) Dieckmann reaction
(c) Sandmeyer reaction
(d) Michael addition
(e) Baeyer-villiger oxidation
4 (a) Explain the role of protecting grps in organic synthesis. Explain how carbonyl,
carboxyl and amino grps are protected during the synthesis?
(b) Mention the heterocyclic nucleus present and also the steps involved in the
synthesis of
(i) Antipyrin (ii) Chlorpromazine (7+8)
5 (a) Explain the following terms with one example each.
(i) Retrosynthesis
(ii) Functional grp in terconversion
(iii) Functional grp addition
(iv)Synthon and synthetic reagent
(b) Discuss C ? X disconnections and C ? C disconnections of 1,2-, 1, 3 -, 1, 4-
and 1, 5 ? difunctionalized compnds belonging to alcohols and carbonyl
compnds. (8+7)
6 (a) Explain E
1
and E
2
elimination reactions with their mechanism and
stereochemistry.
(b) Discuss Saytzeff and Hoffman rules. (9+6)
7 (a) Explain the structure, stability and important reactions of carbanions.
(b) Discuss mechanism and synthetic applications of following agents:
(i) Aliminium isopropoxide
(ii) Wittig reagent (8+7)
...2



FirstRanker.com - FirstRanker's Choice