Download OU M.Pharma Ph.Chemistry 1st Sem 2019 13153 PCI Chemistry Of Natural Products Question Paper

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Code No. 13153/ PCI

FACULTY OF PHARMACY

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M. Pharmacy (Pharmaceutical Chemistry) | — Semester (PCl) (Main & Backlog)

Examination, February 2019

Subject : Chemistry of Natural Products

Time : 3 hrs Max. Marks : 75

Note : Answer any FIVE questions. All questions carry equal marks.

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1. a) What are alkaloids? Classify alkaloids by giving one example for each class.
   b) Write the general methods to determine the structure of alkaloids. 3+12
2. How natural products acted as leads for the following classes of drugs? Explain.
   a) Macrolide and B-lactam antibiotics
   b) Cardiovascular drugs 8+7

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3. a) Give classification, isoprene and special isoprene rules of interpenoids.
   b) Discuss in brief the structural elucidation of citral and retinol. 3+12
4. Write a note on :
   a) Chemistry and physiological significance of vitamins
   b) Gene therapy 9+6

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5. How do you characterize the structure of following natural compounds using IR, ¹H NMR and ¹³C NMR spectral data? (Write approximate spectral values)
   a) Morphine
   b) Penicillin G
   c) Vitamin-D
   d) Quercetin
   

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   e) Digoxin 5x3=15
6. Write a note on:
   a) Chemistry of contraceptive agents
   b) Stereochemistry and nomenclature of steroids
   c) Recombinant DNA technology and drug discovery 3x5=15

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7. Discuss in detail the structural elucidation of morphine. 15
8. a) Write down the active constituents present in the following crude drugs with structures
   i) Swertia chirata ii) Phyllanthus niruri
   iii) Curcuma longa iv) Gymnema sylvestre 4x2=8
   b) Write the structural elucidation of Quercetin. 7

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