Download OU M.Pharma Ph.Chemistry 1st Sem 2019 13153 PCI Chemistry Of Natural Products Question Paper

Download OU (Osmania University) M.Pharma-Ph.Chemistry (Master of Pharmacy) 1st Sem 2019 13153 PCI Chemistry Of Natural Products Previous Question Paper

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Code No. 13153 / PCI
FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutical Chemistry) I ? Semester (PCI) (Main & Backlog)
Examination, February 2019
Subject : Chemistry of Natural Products
Time : 3 hrs Max. Marks : 75
Note : Answer any FIVE questions. All questions carry equal marks.
1 a) What are alkaloids? Classify alkaloids by giving one example for each class.
b) Write the general methods to determine the structure of alkaloids. 3+12
2 How natural products acted as leads for the following classes of drugs? Explain.
a) Macrolide and ?-lactam antibiotics
b) Cardiovascular drugs 8+7
3 a) Give classification, isoprene and special isoprene rules of interpenoids.
b) Discuss in brief the structural elucidation of citral and retinol. 3+12
4 Write a note on :
a) Chemistry and physiological significance of vitamins
b) Gene therapy 9+6
5 How do y characterize the structure of following natural compnds using IR,
1
H NMR and
13
C NMR spectral data? (Write approximate spectral values)
a) Morphine
b) Penicillin G
c) Vitamin-D
d) Quercetin
e) Digoxin 5 x 3 = 15
6 Write a note on :
a) Chemistry of contraceptive agents
b) Stereochemistry and nomenclature of steroids
c) Recombinant DNA technology and drug discovery 3 x 5 = 15
7 Discuss in detail the structural elucidation of morphine. 15
8 a) Write down the active constituents present in the following crude drugs with
structures
i) Swertia chirata ii) Phyllanthus niruri
iii) Curcuma longa iv) Gymnema sylvestre 4 x 2 = 8
b) Write the structural elucidation of Quercetin. 7
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