Download OU M.Pharma Ph.Chemistry 1st Sem 2019 13307 PCI Advanced Organic Chemistry I Question Paper

FirstRanker.com

Code No. 13307 / PCI

FACULTY OF PHARMACY

--- Content provided by⁠ FirstRanker.com ---

M. Pharmacy (Pharmaceutical Chemistry) I Semester (Suppl.) Examination, August 2019

Subject : Advanced Organic Chemistry - I

Time : 3 hrs Max. Marks : 75

Note : Answer any FIVE questions. All questions carry equal marks.

1. a) Discuss the method of formation, stability and important reactions of free radicals and carbanions. 8

   --- Content provided by​ FirstRanker.com ---

   b) Write the mechanism and stereochemistry of E1 and E2 eliminations. 7

2. Write a method of preparation, mechanism and applications of following synthetic reagents (any three)

   a) Diazomethane b) Osmium tetroxide

   c) Triphenyl phosphine d) Wittig reagent

   --- Content provided by​ FirstRanker.com ---

   e) Aluminium isopropoxide 3x5=15

3. a) Discuss the important guidelines for disconnection of molecules.

   b) What is FGI, FGA, synthon and synthetic reagent? Explain giving one example for each.

   c) Discuss c-x disconnections in alcohols and carbonyl compounds. 6+4+5

   --- Content provided by FirstRanker.com ---

4. Write the mechanism and synthetic applications of (any three)

   a) Doebner-Miller reaction b) Sandmeyer reaction

   c) Shapiro and Suzuki reaction d) Mannich-addition 3x5=15

--- Content provided by FirstRanker.com ---

5. a) Write a note on (any two)

   i) Knorr pyrazole synthesis

   ii) Combes Quinaline synthesis

   iii) Traube purine synthesis 2x4=8

   b) Explain the methods for protection and deprotection of

   --- Content provided by FirstRanker.com ---

   i) Carbonyl grp ii) Amino grp 7

6. Mention the heterocyclic nucleus present and also the steps involved in the synthesis of following drugs (any three)

   i) Miconazole ii) Antipyrin

   iii) Chlorpromazine iv) Quinacrine

   --- Content provided by​ FirstRanker.com ---

   iv) Triamterene 5x5=15

7. a) Discuss any two rearrangement reactions.

   b) Explain mechanism in SN1 reaction and also mention its stereochemistry.

   c) What is Saytzeff's rule? Explain with example? 6+5+4

   --- Content provided by⁠ FirstRanker.com ---

8. Write a note on (any three)

   a) Vilsmeyer-Haack reaction b) Wilkinson reagent

   c) Sharpless asymmetric epoxidation d) BOP reagent 3x5=15

--- Content provided by​ FirstRanker.com ---

FirstRanker.com