Download OU M.Pharma Ph.Chemistry 1st Sem 2019 13309 PCI Chemistry Of Natural Products Question Paper

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Code No. 13309/ PCI

FACULTY OF PHARMACY

M. Pharmacy (Pharmaceutical Chemistry) | — Semester (Suppl.) Examination, August 2019

Subject : Chemistry of Natural Products

Time : 3 hrs Max. Marks : 75

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Note : Answer any FIVE questions. All questions carry equal marks.

1. a) Discuss the structural elucidation of reserpine.
   b) Give classification, isolation and biological activity of alkaloids. 9+6
2. How natural products acted as leads for the following classes of drugs? Explain.
   a) Drugs affecting CNS
   

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   b) Anticancer drugs
   c) Cardiovascular drugs 5+5+5
3. a) Discuss the general methods to elucidate the structure of terpenoids.
   b) Write the structural elucidation of menthol. 8+7
4. a) Give the chemistry and physiological significance of Vitamin A, Vitamin C and Folic acid.
   

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   b) Explain how recombinant DNA technology helped in new drug discovery. 8+7
5. a) Write a note on Sapogenins and cardiac glycosides.
   b) Discuss chemistry of contraceptive agents.
   c) Discuss clinical applications and recent advances in gene therapy. 5+5+5
6. How do you characterize the following natural compounds using IR, ¹H NMR and ¹³C NMR spectral values? Give approximate spectral values.
   

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   a) Quercetin b) Vitamin-D
   c) Morphine d) Benzyl penicillin
   e) Digoxin 5x3=15
7. a) List the active constituents present in the following crude drugs with their structures.
   i) Curcuma longa linn ii) Trigonella foenumgraccum
   

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   iii) Pterocarpus marsupiam iv) Swertia chirata 4x2=8
   b) Write in brief the structural elucidation of phytol. 7
8. Write a note on : (5+5+5)
   a) Hofmann exhaustive methylation
   b) Stereochemistry and nomenclature of steroids
   

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   c) Chemistry of flavanoids

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