Download OU M.Pharma Ph.Chemistry 1st Sem 2020 6112PCI Chemistry Of Natural Products Question Paper

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Code No: 6112/PCI

FACULTY OF PHARMACY

M. Pharmacy (Pharmaceutical Chemistry) I-Semester (PCI) (Main & Backlog)

Examination, 2020

Subject: Chemistry of Natural products

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Time: 3 Hrs Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1. a) Define Alkaloids and write the general methods to determine the structure of Alkaloids.
   b) Write the special isoprene rule in terpenoids. (8+7)
2. Write the structural elucidation of any two drugs. (8+7)

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3. Write how the natural products acts as a leads in the following classes of drugs
   1. Antimalarial drugs and analogues
   2. Cardiovascular drugs (8+7)
4. Write the structural characterization of following compounds using IR, ¹H NMR, ¹³C NMR and Mass spectral data (Write approximate values) 5x3=15
   1. Quercetin
   2. Vitamin D

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   3. Digoxin
   4. Camphor
   5. Pencillin G
5. Write down the active constituents present in the following crude drugs with Structures (minimum three from each crude drug)
   1. Curcuma longa

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   2. Pterocarpus marsupium
   3. Gymnema sylvestre
   4. Phyllanthus niruri
   5. Swertia chirata (5x3=15)

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6. a) Write a note on chemistry and physiological significance of following vitamins
   1. Vitamin A
   2. Vitamin B 12
   3. Vitamin C (3x3=9)
   b) Write the structural elucidation of quercetin
7. Discuss about
   1. Chemistry of sapogenins and cardiac glycosides (9+6)

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   2. Gene therapy
8. Write the structural elucidation of (8+7)
   1. Citral
   2. Carotenoids

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