Download OU M.Pharma Ph.Chemistry 1st Sem 2018 1163PCI Chemistry Of Natural Products Question Paper

Download OU (Osmania University) M.Pharma-Ph.Chemistry (Master of Pharmacy) 1st Sem 2018 1163PCI Chemistry Of Natural Products Previous Question Paper

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Code No. 1163/PCI
FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutical Chemistry) I-Semester (PCI) (Main) Examination,
February 2018
Subject: Chemistry of Natural Products
Time: 3 Hrs Max. Marks: 75
Note: Answer any five questions. All questions carry equal marks.
1 Explain how natural products acted as lead molecules while designing drugs?
Explain by taking any three clesses of drugs. (15)
2 (a) Write the classification and biological activity of alkaloids.
(b) Discuss the structural elucidation of Reserpine (OR) Ephedrine. (5+10)
3 (a) Discuss the stereochemistry and nomenclature of steroids.
(b) Write a note on contraceptive steroids.
(c) Explain structural elucidation of Quercetin (5+5+5)
4 (a) Explain isoperene rule and discuss general methods for structural
elucidation of terpenoids.
(b) Discuss the chemistry and physiological significance of Vitamin A. (10+5)
5 Discuss the structural elucidation of any one monoterpenoid and one
Diterpenoid. (15)
6 How do y characterize the structure of following natural compnds using
IR,
1
HNMR and
13
CNMR ? (Give approximate specral values).
(a) Penicillin - G
(b) Morphine
(c) Quercetin
(d) Digoxin
(e) Vitamin ? D (5x3)
7 (a) Write a note on Recombinant DNA technology and how it helped in new
drug discovery?
(b) Write down the active constituents present in the following crude drugs
by giving the structures for two compnds each:
(i) Gymnema sylvestre (ii) Trigonella foenumgraccum
(iii) Phyllanthus niruri (iv) Curcuma longa (7+8)
8 Write a note on :
(a) Anti inflammatory steroids
(b) Gene therapy
(c) Chemistry and biological significance of Vitamin B
1
, B
2
and B
12
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