Download OU M.Pharma Ph.Chemistry 1st Sem 2018 1294PCI Advanced Medicinal Chemistry Question Paper

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Code No. 1294/PCI

FACULTY OF PHARMACY

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M. Pharmacy (Pharmaceutical Chemistry) I-Semester (PCI) (Suppl.) Examination, August 2018

Subject: Advanced Medicinal Chemistry

Time: 3 Hrs Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1. 1. Discuss about various stages involved in the drug discovery.

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   2. Explain the theories of drug receptor interactions. (8+7)
2. 1. Define prodrug and discuss the applications of prodrugs with suitable examples.
   2. Discuss the strategies to overcome the drug resistance to antibiotics. (9+6)

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3. 1. Give the classification of H1 and H2 histamine receptor antagonists with suitable examples.
   2. Discuss how chirality of drug molecule influences the pharmacological action? (9+6)
4. 1. Give the classification of enzyme inhibitors with suitable examples.
   2. Discuss the rational design of reversible enzyme inhibitors. (10+5)

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5. 1. Define peptidomimetics and discuss the various types of peptidomimetics.
   2. Explain the various approaches used in peptide modifications in peptidomimetics design. (7+8)
6. 1. Classify antineoplastic drugs with suitable examples and discuss the mechanism of action of methotrexate and chlorambucil.

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   2. Discuss the chemistry of prostaglandins. Write the structures of therapeutically useful prostaglandins. (9+6)
7. Write a note on
   1. Sources for lead identification
   2. Drug receptor interactions (7+8)

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8. 1. What are bio-isosters? Discuss their applications in analogue design.
   2. Write a note on cyclooxygenase inhibitors. (8+7)

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