Download OU M.Pharma Ph.Chemistry 1st Sem 2018 1295PCI Chemistry Of Natural Products Question Paper

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Code No. 1295/PCI

FACULTY OF PHARMACY

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M. Pharmacy (Pharmaceutical Chemistry) I-Semester (PCI) (Supple.) Examination, August 2018

Subject: Chemistry of Natural Products

Time: 3 Hrs Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1. Discuss the structural elucidation of morphine (OR) reserpine. (15)

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2. Discuss how natural products acted as leads while designing the drugs? Explain by taking any three categories of drugs.
3. (a) What are flavanoids? Discuss the structural elucidation of quercetin.
   (b) Discuss the chemistry and mechanism of contraceptive steroids. (7+8)
4. What are isoprene and special isoprene rules? Discuss the structural elucidation of any one monoterpeniod and one diderpenoid. (15)
5. Write the approximate spectral values for the following natural drugs in IR, "HNMR and "*CNMR spectra. (5x3)
   

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   (a) Morphine
   (b) Any one Digitalis glycoside
   (c) Benzyl penicillin
   (d) Quercetin
   (e) Vitamin — D

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6. Write a note on : (3x5)
   (a) Recombinant DNA technology-and drug discovery
   (b) Chemistry of Vitamin A
   (c) Stereochemistry and.nomenclature of steroids
7. (a) Explain how natural-products acted as leads in the discovery of new B-lactam antibiotics and.macrolide antibiotics.
   

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   (b) Discuss the structural elucidation of Ephedrine. (7+8)
8. (a) List the active constituents that are isolated from the following crude drugs with their medicinal use
   (i) Pterocarpus marsupiam
   (ii) Swertia chirata
   (iii) Phyllanthus niruri
   

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   (iv) Curcuma longa Linn (8)
   (b)Write a note on Gene therapy. (7)

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