Download OU M.Pharma Ph.Chemistry 1st Sem 2019 13152 PCI Advanced Medicinal Chemistry Question Paper

Download OU (Osmania University) M.Pharma-Ph.Chemistry (Master of Pharmacy) 1st Sem 2019 13152 PCI Advanced Medicinal Chemistry Previous Question Paper

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Code No. 13152 / PCI
FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutical Chemistry) I ? Semester (Main & Backlog)
Examination, February 2019
Subject : Advanced Medicinal Chemistry
Time : 3 hrs Max. Marks : 75
Note : Answer any FIVE questions. All questions carry equal marks.
1 a) Discuss the concept of rational drug design in new drug discovery.
b) Write a note on the srces of lead discovery. 9+6
2 a) Explain the development of resistance to anticancer drugs and underlying
mechanisms.
b) How does ADME properties are improved thrgh prodrug design? 8+7
3 a) Give an accnt on COX -II inhibitors.
b) Classify adrenergic antagonists and discuss the SAR of B-blockers. 8+7
4 a) Define drug resistance and discuss the strategies to overcome resistance to
antibiotics.
b) Classify anti convulsants with examples and discuss the SAR of
Benzodiazepines. 8+7
5 a) Give an accnt on rational design of enzyme inhibitors.
b) Explain abt Non -covalently binding enzyme inhibitors. 8+7
6 a) Write a note on modification of amino acid in peptidomimetic design.
b) Write a note on manipulation of peptide back bone and incorporation of
conformational constraints in peptidomimetic drug design. 8+7
7 a) Discuss, how does the stereochemistry of drug influences absorption, distribution
and elimination.
b) Explain the concept of bio-isosterism. 10+5
8 Write a short note on :
a) ACE inhibitors b) H2 antihistaminics 8+7
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