Download OU M.Pharma Ph.Chemistry 1st Sem 2019 13152 PCI Advanced Medicinal Chemistry Question Paper

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Code No. 13152 / PCI

FACULTY OF PHARMACY

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M. Pharmacy (Pharmaceutical Chemistry) I Semester (Main & Backlog) Examination, February 2019

Subject : Advanced Medicinal Chemistry

Time : 3 hrs Max. Marks : 75

Note : Answer any FIVE questions. All questions carry equal marks.

1. a) Discuss the concept of rational drug design in new drug discovery.
   

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   b) Write a note on the sources of lead discovery. 9+6
2. a) Explain the development of resistance to anticancer drugs and underlying mechanisms.
   b) How does ADME properties are improved through prodrug design? 8+7
3. a) Give an account on COX -l inhibitors.
   b) Classify adrenergic antagonists and discuss the SAR of B-blockers. 8+7

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4. a) Define drug resistance and discuss the strategies to overcome resistance to antibiotics.
   b) Classify anti convulsants with examples and discuss the SAR of Benzodiazepines. 8+7
5. a) Give an account on rational design of enzyme inhibitors.
   b) Explain about Non -covalently binding enzyme inhibitors. 8+7
6. a) Write a note on modification of amino acid in peptidomimetic design.
   

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   b) Write a note on manipulation of peptide back bone and incorporation of conformational constraints in peptidomimetic drug design. 8+7
7. a) Discuss, how does the stereochemistry of drug influences absorption, distribution and elimination.
   b) Explain the concept of bio-isosterism. 10+5
8. Write a short note on :
   a) ACE inhibitors b) H2 antihistaminics 8+7

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